1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Olodaterol hydrochloride

Olodaterol hydrochloride  (Synonyms: BI1744 hydrochloride)

Cat. No.: HY-14301A Purity: 98.87%
COA Handling Instructions

Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.

For research use only. We do not sell to patients.

Olodaterol hydrochloride Chemical Structure

Olodaterol hydrochloride Chemical Structure

CAS No. : 869477-96-3

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1 mg USD 71 In-stock
5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 450 In-stock
50 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Olodaterol hydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Olodaterol hydrochloride

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis[1][2][3].

IC50 & Target

β2 adrenoceptor

0.1 nM (EC50)

In Vitro

Olodaterol hydrochloride (0.1~10 nM; fibroblasts) interferes with FGF-induced phosphorylation of signalling cascades[2].
Olodaterol hydrochloride (0.001~10 nM; fibroblasts) attenuates growth factor-induced motility and proliferation[2].
Olodaterol hydrochloride (0.001~1000 nM; 0.5 hours; fibroblasts) increases intracellular cAMP in a concentration-dependent manner. Olodaterol hydrochloride (0~10 nM; 0.5 hours; fibroblasts) concentration-dependently inhibits the PICP increase with maximal efficacy of 70 % at 10 nM. Olodaterol hydrochloride has a subnanomolar affinity for the β2-AR (pKi=9.14) and is selective for this receptorin comparison with the β1-AR and β3-AR subtypes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Fibroblasts
Concentration: 0.1~10 nM
Incubation Time:
Result: Interfered with FGF-induced phosphorylation of signalling cascades.

Cell Proliferation Assay[2]

Cell Line: Fibroblasts
Concentration: 0.001~10 nM
Incubation Time:
Result: Attenuated growth factor-induced motility and proliferation.
In Vivo

Olodaterol (1 mg/kg; inhal.; 21 days) accelerats body weights recovery back to control levels (at day 21) and attenuats TGF-β-induced lung fibrosis[2].
Olodaterol (0.1~3 μg/kg; inhal.; 5 hours) induces a dose-dependent bronchoprotection[3].
Olodaterol (0.3 and 0.6 μg/kg; inhal.; 24 hours) induces a maximal bronchoprotection of approximately 60 % after 0.5 hours[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lung fibrosis C57BL/6 mice
Dosage: 1 mg/mL
Administration: Inhal.; 21 days
Result: Accelerated body weight recovery back to control levels (at day 21) and attenuated TGF-β-induced lung fibrosis.
Animal Model: Guinea Pigs
Dosage: 0.1~3 μg/kg
Administration: Inhal.; 5 hours
Result: Induced a dose-dependent bronchoprotection.
Animal Model: Dogs
Dosage: 0.3 and 0.6 μg/kg
Administration: Inhal.; 24 hours
Result: Olodaterol (0.6 μg/kg) induced a maximal bronchoprotection of approximately 60 % after 0.5 h.
Clinical Trial
Molecular Weight

422.90

Formula

C21H27ClN2O5

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1NC2=CC(O)=CC([C@@H](O)CNC(C)(C)CC3=CC=C(OC)C=C3)=C2OC1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (591.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3646 mL 11.8231 mL 23.6463 mL
5 mM 0.4729 mL 2.3646 mL 4.7293 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 14.29 mg/mL (33.79 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.3646 mL 11.8231 mL 23.6463 mL 59.1156 mL
5 mM 0.4729 mL 2.3646 mL 4.7293 mL 11.8231 mL
10 mM 0.2365 mL 1.1823 mL 2.3646 mL 5.9116 mL
15 mM 0.1576 mL 0.7882 mL 1.5764 mL 3.9410 mL
20 mM 0.1182 mL 0.5912 mL 1.1823 mL 2.9558 mL
25 mM 0.0946 mL 0.4729 mL 0.9459 mL 2.3646 mL
30 mM 0.0788 mL 0.3941 mL 0.7882 mL 1.9705 mL
40 mM 0.0591 mL 0.2956 mL 0.5912 mL 1.4779 mL
50 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1823 mL
60 mM 0.0394 mL 0.1971 mL 0.3941 mL 0.9853 mL
80 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.7389 mL
100 mM 0.0236 mL 0.1182 mL 0.2365 mL 0.5912 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Olodaterol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Olodaterol hydrochloride
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