1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Olodaterol hydrochloride

Olodaterol hydrochloride (Synonyms: BI1744 hydrochloride)

Cat. No.: HY-14301A Purity: 99.70%
Handling Instructions

Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.

For research use only. We do not sell to patients.

Olodaterol hydrochloride Chemical Structure

Olodaterol hydrochloride Chemical Structure

CAS No. : 869477-96-3

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Based on 1 publication(s) in Google Scholar

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Description

Olodaterol (BI1744) hydrochloride is a selective, long acting β2-adrenoceptor2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis[1][2][3].

IC50 & Target

β2 adrenoceptor

0.1 nM (EC50)

In Vitro

Olodaterol hydrochloride (0.1~10 nM; fibroblasts) interferes with FGF-induced phosphorylation of signalling cascades[2].
Olodaterol hydrochloride (0.001~10 nM; fibroblasts) attenuates growth factor-induced motility and proliferation[2].
Olodaterol hydrochloride (0.001~1000 nM; 0.5 hours; fibroblasts) increases intracellular cAMP in a concentration-dependent manner. Olodaterol hydrochloride (0~10 nM; 0.5 hours; fibroblasts) concentration-dependently inhibits the PICP increase with maximal efficacy of 70 % at 10 nM. Olodaterol hydrochloride has a subnanomolar affinity for the β2-AR (pKi=9.14) and is selective for this receptorin comparison with the β1-AR and β3-AR subtypes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Fibroblasts
Concentration: 0.1~10 nM
Incubation Time:
Result: Interfered with FGF-induced phosphorylation of signalling cascades.

Cell Proliferation Assay[2]

Cell Line: Fibroblasts
Concentration: 0.001~10 nM
Incubation Time:
Result: Attenuated growth factor-induced motility and proliferation.
In Vivo

Olodaterol (1 mg/kg; inhal.; 21 days) accelerats body weights recovery back to control levels (at day 21) and attenuats TGF-β-induced lung fibrosis[2].
Olodaterol (0.1~3 μg/kg; inhal.; 5 hours) induces a dose-dependent bronchoprotection[3].
Olodaterol (0.3 and 0.6 μg/kg; inhal.; 24 hours) induces a maximal bronchoprotection of approximately 60 % after 0.5 hours[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lung fibrosis C57BL/6 mice
Dosage: 1 mg/mL
Administration: Inhal.; 21 days
Result: Accelerated body weight recovery back to control levels (at day 21) and attenuated TGF-β-induced lung fibrosis.
Animal Model: Guinea Pigs
Dosage: 0.1~3 μg/kg
Administration: Inhal.; 5 hours
Result: Induced a dose-dependent bronchoprotection.
Animal Model: Dogs
Dosage: 0.3 and 0.6 μg/kg
Administration: Inhal.; 24 hours
Result: Olodaterol (0.6 μg/kg) induced a maximal bronchoprotection of approximately 60 % after 0.5 h.
Molecular Weight

422.90

Formula

C₂₁H₂₇ClN₂O₅

CAS No.
SMILES

O=C1NC2=CC(O)=CC([[email protected]@H](O)CNC(C)(C)CC3=CC=C(OC)C=C3)=C2OC1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (591.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3646 mL 11.8231 mL 23.6463 mL
5 mM 0.4729 mL 2.3646 mL 4.7293 mL
10 mM 0.2365 mL 1.1823 mL 2.3646 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

OlodaterolBI1744BI 1744BI-1744Adrenergic ReceptorBeta ReceptorInhaledLong-actingUltra-LABAPotentCOPDFibrosisInhibitorinhibitorinhibit

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Olodaterol hydrochloride
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