1. Anti-infection
  2. HCV
  3. RO-9187

RO-9187 

Cat. No.: HY-10870 Purity: ≥98.0%
Handling Instructions

RO-9187 is a potent inhibitor of HCV virus replication with an IC50 of 171 nM.

For research use only. We do not sell to patients.

RO-9187 Chemical Structure

RO-9187 Chemical Structure

CAS No. : 876708-03-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 268 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 268 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 244 In-stock
Estimated Time of Arrival: December 31
10 mg USD 319 In-stock
Estimated Time of Arrival: December 31
50 mg USD 869 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

RO-9187 is a potent inhibitor of HCV virus replication with an IC50 of 171 nM.

IC50 & Target

IC50: 171 nM (HCV)[1]

In Vitro

RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

284.23

Formula

C₉H₁₂N₆O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 7.14 mg/mL (25.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5183 mL 17.5914 mL 35.1828 mL
5 mM 0.7037 mL 3.5183 mL 7.0366 mL
10 mM 0.3518 mL 1.7591 mL 3.5183 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats: A 2-week oral range finding toxicity study is performed with RO-9187 and ribavirin in Hanover-Wistar rats. Five male and five female rats in each of five treatment groups are administered once daily doses of vehicle, 200, 600, or 2000 mg/kg RO-9187 or 200 mg/kg ribavirin by oral gavage for 14 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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RO-9187
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HY-10870
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