1. Epigenetics
    Apoptosis
  2. MicroRNA
    Apoptosis
  3. Targapremir-210

Targapremir-210 (Synonyms: TGP-210)

Cat. No.: HY-15861 Purity: 98.02%
Handling Instructions

Targapremir-210 (TGP-210) is a potent and selective miR-210 inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM).

For research use only. We do not sell to patients.

Targapremir-210 Chemical Structure

Targapremir-210 Chemical Structure

CAS No. : 1049722-30-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 340 In-stock
Estimated Time of Arrival: December 31
5 mg USD 260 In-stock
Estimated Time of Arrival: December 31
10 mg USD 460 In-stock
Estimated Time of Arrival: December 31
25 mg USD 920 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Targapremir-210 (TGP-210) is a potent and selective miR-210 inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM)[1].

IC50 & Target

IC50: 200 nM (miR-210, in MDA-MB-231 cells)[1].

In Vitro

Targapremir-210 decreases mature miR-210 levels in MDA-MB-231 cells cultured under hypoxic conditions, with an IC50 of ∼200 nM[1].
Targapremir-210 (200 nM) induces MDA-MB-231 cells apoptosis is selective for the hypoxic environment. Targapremir-210 induces cells apoptosis under hypoxic conditions and does not induce apoptosis in MDA-MB-231 cells cultured in normoxia[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Targapremir-210 (100 μL of 200 nM; single i.p. injection) impedes MDA-MB-231 triple negative breast cancer (TNBC) cells proliferation in vivo. Targapremir-210 is able to reach the tumor and sustain for the entire 21-day period, and decreases tumor burden in a TNBC mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice were subcutaneously transplanted cell suspension into breast fat pads[1].
Dosage: 100 μL of 200 nM
Administration: Single i.p. injection 24 h post-transplantation
Result: Decreased tumor growth as assessed by luciferase signal intensity and mass of the resected tumor.
Molecular Weight

592.69

Formula

C₃₂H₃₆N₁₀O₂

CAS No.

1049722-30-6

SMILES

O=C(NCCCN=[N+]=[N-])CCCOC1=CC=CC(C2=NC3=CC=C(C4=NC5=CC=C(N6CCN(C)CC6)C=C5N4)C=C3N2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (421.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6872 mL 8.4361 mL 16.8722 mL
5 mM 0.3374 mL 1.6872 mL 3.3744 mL
10 mM 0.1687 mL 0.8436 mL 1.6872 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Targapremir-210TGP-210Targapremir210Targapremir 210TGP210TGP 210MicroRNAApoptosismiRNAmiR-210MDA-MB-231cells triplenegativebreastcancerTNBCInhibitorinhibitorinhibit

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Product Name:
Targapremir-210
Cat. No.:
HY-15861
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