PCSK9
Proprotein convertase subtilisin/kexin type 9
The protein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene located on human chromosome 1. It is the ninth member of the protein convertase family, a group of enzymes that can activate homologous genes found in many species[1]. PCSK9 is a liver-synthesized protease that plays a major role in regulating the levels of low-density lipoprotein receptors (LDLR) on the surface of liver cells and can inhibit the LDLR recycling pathway. PCSK9 binds to LDLR on the surface of liver cells, escorts LDLR to lysosomes for degradation, and prevents LDLR from recirculating to the cell membrane, effectively increasing the level of circulating LDL. Therefore, inhibiting the activity of the PCSK9 protease can down-regulate circulating LDL levels. PCSK9 is closely associated with various cardiovascular diseases, especially hypercholesterolemia and atherosclerosis[2].
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PCSK9 Related Products (96)
Related Products (96)
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SPC4061 sodium
0 ImagesCat. No.: HY-148689A
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PCSK9-IN-1
0 ImagesCat. No.: HY-134482CAS No.: 2730022-10-1PCSK9-IN-1 is a novel and highly potent cyclic peptide PCSK9 inhibitor with a Ki value of 1.46 nM.
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Cepadacursen sodium
0 ImagesCat. No.: HY-158825CAS No.: 2252375-14-5Synonyms: CIVI007 sodiumCepadacursen sodium is a liver-targeting antisense oligonucleotide (ASO), inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) protein synthesis. Cepadacursen sodium can be used for hypercholesterolemia research and the prevention of atherosclerotic cardiovascular disease (ASCVD).
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Anacetrapib (Standard)
0 ImagesSynonyms: MK-0859 (Standard)Anacetrapib (Standard) is the analytical standard of Anacetrapib. This product is intended for research and analytical applications. Anacetrapib is a potent CETP inhibitor, with IC50s of 7.9±2.5 nM and 11.8±1.9 nM for rhCETP and C13S CETP mutant, respectively.
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SBC-110736 (Standard)
0 ImagesCat. No.: HY-101832RCAS No.: 1629166-02-4SBC-110736 (Standard) is the analytical standard of SBC-110736 (HY-101832). This product is intended for research and analytical applications. SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1.
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AZD8233 sodium scrambled negative control
0 ImagesCat. No.: HY-158827BAZD8233 sodium scrambled negative control is the sequence scrambled negative control of AZD8233 sodium.
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BRD8518
0 ImagesCat. No.: HY-161938CAS No.: 1565828-01-4
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Obicetrapib hemicalcium
0 ImagesCat. No.: HY-18778CCAS No.: 866399-89-5Synonyms: TA-8995 hemicalcium; DEZ-001 hemicalcium; AMG-899 hemicalciumObicetrapib hemicalcium (TA-8995 hemicalcium) is an orally active cholesteryl ester transfer protein (CETP) inhibitor. Obicetrapib hemicalcium shifts the plasma lipoprotein profile toward more HDL-C particles, reduces circulating PCSK9 levels, increases hepatic LDLR expression and LDLR mRNA levels, and promotes hepatic clearance of VLDL remnants. Obicetrapib hemicalcium increases the number of large HDL particles, reduces the number and area of atherosclerotic lesions and alleviates lesion severity, increases the proportion of unaffected arterial segments, improves lesion stability, and promotes regression of aortic root lesions. Obicetrapib hemicalcium also exerts a synergistic effect with Ezetimibe (HY-17376) to reduce non-HDL-C levels and improve atherosclerosis. Obicetrapib hemicalcium can be used in studies related to atherosclerosis and dyslipidemia.
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AZD8233
0 ImagesCat. No.: HY-158827CAS No.: 2604215-74-7
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Dim16 hydrochloride
0 ImagesCat. No.: HY-149310ACAS No.: 2743448-41-9Dim16 hydrochloride is a dual PCSK9 inhibitor and HMG-CoAR inhibitor, with an IC50 of 0.8 nM against human PCSK9 and an IC50 of 146.8 μM against HMG-CoAR. Dim16 hydrochloride disrupts the PCSK9-LDLR protein-protein interaction, inhibits the catalytic activity of HMG-CoAR, enhances cellular uptake of extracellular LDL, and suppresses PCSK9-induced platelet aggregation. Dim16 hydrochloride can be used in research related to hypercholesterolemia.
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Cepadacursen sodium scrambled negative control
0 ImagesCat. No.: HY-158825ACepadacursen sodium scrambled negative control is the sequence scrambled negative control of Cepadacursen sodium.
