2743448-41-9
Chemical Structure
Dim16 hydrochloride
- CAS No.: 2743448-41-9
- Formula:C29H39ClIN5
- Molecular Weight:620.01
IUPAC Name: 5-(1-(4,4-dimethylpentyl)-2'-iodo-5-(naphthalen-2-yl)-1H,3'H-[2,4'-biimidazol]-3'-yl)-N-methylpentan-1-amine hydrochloride
InChIKey: AVNFEUGWJIFFJZ-UHFFFAOYSA-N
SMILES: IC1=NC=C(N1CCCCCNC)C2=NC=C(N2CCCC(C)(C)C)C3=CC4=C(C=CC=C4)C=C3.Cl
Biological Activity: Dim16 hydrochloride is a dual PCSK9 inhibitor and HMG-CoAR inhibitor, with an IC50 of 0.8 nM against human PCSK9 and an IC50 of 146.8 μM against HMG-CoAR. Dim16 hydrochloride disrupts the PCSK9-LDLR protein-protein interaction, inhibits the catalytic activity of HMG-CoAR, enhances cellular uptake of extracellular LDL, and suppresses PCSK9-induced platelet aggregation. Dim16 hydrochloride can be used in research related to hypercholesterolemia[1].
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Dim16 hydrochloride | Dim16 hydrochloride is a dual PCSK9 inhibitor and HMG-CoAR inhibitor, with an IC50 of 0.8 nM against human PCSK9 and an IC50 of 146.8 μM against HMG-CoAR. Dim16 hydrochloride disrupts the PCSK9-LDLR protein-protein interaction, inhibits the catalytic activity of HMG-CoAR, enhances cellular uptake of extracellular LDL, and suppresses PCSK9-induced platelet aggregation. Dim16 hydrochloride can be used in research related to hypercholesterolemia. | |||||||||||||||||||||
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Keywords
