PCSK9 Degrader
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PCSK9 degrader 1
0 ImagesCat. No.: HY-130245Purity: 98.33%PCSK9 degrader 1 is a HyT-like PCSK9 degrader with a Ki of 107 nM. PCSK9 degrader 1 binds to the allosteric pocket between the catalytic domain and C-terminal domain of PCSK9. While maintaining key interactions with this protein, it extends the proteasome-recruiting moiety, thereby driving degradation via the proteasomal pathway. PCSK9 degrader 1 induces the degradation of both the precursor and mature forms of PCSK9, with DC50 values of 4.8 μM and 3.4 μM respectively, and does not significantly affect cell viability or the expression of housekeeping proteins. PCSK9 degrader 1 can be used in the research of coronary heart disease.
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AZD8233 sodium
0 ImagesCat. No.: HY-158827AAZD8233 sodium is an orally active antisense oligonucleotide targeting PCSK9 mRNA. AZD8233 sodium highly specifically reduces PCSK9 mRNA. AZD8233 sodium lowers LDL cholesterol. AZD8233 sodium can be used in research on dyslipidemia.
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(R,R)-PCSK9 degrader 1
0 ImagesCat. No.: HY-130245ACAS No.: 2216703-12-5(R,R)-PCSK9 degrader 1 is an isomer of PCSK9 degrader 1 (HY-130245). (R,R)-PCSK9 degrader 1 is a HyT-like PCSK9 degrader (IC50 of 655.4 nM) , and its PCSK9-binding site does not interfere with the binding of PCSK9 to LDL receptor. (R,R)-PCSK9 degrader 1 can be used in the research of atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, and related cardiovascular and cardiometabolic diseases.
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PCSK9 autophagic degrader 2
0 ImagesCat. No.: HY-176043CAS No.: 2974497-11-3
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AZD8233
0 ImagesCat. No.: HY-158827CAS No.: 2604215-74-7AZD8233 is an orally active antisense oligonucleotide targeting PCSK9 mRNA. AZD8233 highly specifically reduces PCSK9 mRNA. AZD8233 lowers LDL cholesterol. AZD8233 can be used in research on dyslipidemia.
