PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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Aminooxy-PEG2-azide
0 ImagesCat. No.: HY-113931CAS No.: 1043426-13-6Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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NH2-PEG8-acid
0 ImagesNH2-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG8-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Hydroxy-PEG3-CH2-Boc
0 ImagesCat. No.: HY-141209CAS No.: 518044-31-0
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m-PEG5-CH2COOH
0 Imagesm-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Fmoc-NH-PEG8-CH2COOH
0 ImagesFmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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m-PEG1-NHS ester
0 ImagesCat. No.: HY-114512CAS No.: 1027371-75-0
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Biotin-PEG1000-azide
0 ImagesCat. No.: HY-W250928BCAS No.: 956494-20-5Biotin-PEG1000-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Fmoc-NH-PEG8-NHS ester
0 ImagesCat. No.: HY-126880CAS No.: 1334170-03-4
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(S)-2-Amino-3,3-dimethylbutanoic acid
0 Images(S)-2-amino-3,3-dimethylbutanoic acid is a leucine derivative.
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m-Tolylacetic acid
0 ImagesSynonyms: 3-Methylbenzeneacetic acidm-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid. m-Tolylacetic acid can be used for drug intermediate for synthesising more complex molecules.
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NH2-PEG6-CH2CH2COOH
0 ImagesCat. No.: HY-W040257CAS No.: 905954-28-1NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Biotin-PEG4-methyltetrazine
0 ImagesBiotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Thiol-PEG4-alcohol
0 ImagesSynonyms: HS-PEG4-OH
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N-Mal-N-bis(PEG2-NHS ester)
0 ImagesCat. No.: HY-140571CAS No.: 2182601-73-4
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3-(Methylamino)propan-1-ol
0 ImagesCat. No.: HY-W007469CAS No.: 42055-15-2
