2. PROTAC
  3. PROTAC Linkers
  4. Fmoc-NH-PEG8-NHS ester

Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-NH-PEG8-NHS ester Chemical Structure

Fmoc-NH-PEG8-NHS ester Chemical Structure

CAS No. : 1334170-03-4

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25 mg USD 50 In-stock
50 mg USD 80 In-stock
100 mg USD 130 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Fmoc-NH-PEG8-NHS ester Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-NH-PEG8-NHS ester Related Antibodies
Molecular Weight

760.82

Formula

C38H52N2O14
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (131.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3144 mL 6.5719 mL 13.1437 mL
5 mM 0.2629 mL 1.3144 mL 2.6287 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (258 KB) HNMR (133 KB) LCMS (149 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3144 mL 6.5719 mL 13.1437 mL 32.8593 mL
5 mM 0.2629 mL 1.3144 mL 2.6287 mL 6.5719 mL
10 mM 0.1314 mL 0.6572 mL 1.3144 mL 3.2859 mL
15 mM 0.0876 mL 0.4381 mL 0.8762 mL 2.1906 mL
20 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6430 mL
25 mM 0.0526 mL 0.2629 mL 0.5257 mL 1.3144 mL
30 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
40 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8215 mL
50 mM 0.0263 mL 0.1314 mL 0.2629 mL 0.6572 mL
60 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.5477 mL
80 mM 0.0164 mL 0.0821 mL 0.1643 mL 0.4107 mL
100 mM 0.0131 mL 0.0657 mL 0.1314 mL 0.3286 mL
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Fmoc-NH-PEG8-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-NH-PEG8-NHS ester1334170-03-4PROTAC LinkersInhibitorinhibitorinhibit

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