m-PEG1-NHS ester
Based on 1 Customer Validation
m-PEG1-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
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- Pureté : 95.0%
- CAS No.: 1027371-75-0
- Formule: C8H11NO5
- Masse moléculaire:201.18
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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PEGs |
Alkyl/ether |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1027371-75-0
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Appearance Solid
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Masse moléculaire 201.18
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Formule C8H11NO5
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Color White to light yellow
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SMILES
COCCC(ON1C(CCC1=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
H2O : 33.33 mg/mL (165.67 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (497.07 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9707 mL | 24.8534 mL | 49.7067 mL | 124.2668 mL |
| 5 mM | 0.9941 mL | 4.9707 mL | 9.9413 mL | 24.8534 mL | |
| 10 mM | 0.4971 mL | 2.4853 mL | 4.9707 mL | 12.4267 mL | |
| 15 mM | 0.3314 mL | 1.6569 mL | 3.3138 mL | 8.2845 mL | |
| 20 mM | 0.2485 mL | 1.2427 mL | 2.4853 mL | 6.2133 mL | |
| 25 mM | 0.1988 mL | 0.9941 mL | 1.9883 mL | 4.9707 mL | |
| 30 mM | 0.1657 mL | 0.8284 mL | 1.6569 mL | 4.1422 mL | |
| 40 mM | 0.1243 mL | 0.6213 mL | 1.2427 mL | 3.1067 mL | |
| 50 mM | 0.0994 mL | 0.4971 mL | 0.9941 mL | 2.4853 mL | |
| 60 mM | 0.0828 mL | 0.4142 mL | 0.8284 mL | 2.0711 mL | |
| 80 mM | 0.0621 mL | 0.3107 mL | 0.6213 mL | 1.5533 mL | |
| 100 mM | 0.0497 mL | 0.2485 mL | 0.4971 mL | 1.2427 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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