2. PROTAC
  3. PROTAC Linkers
  4. m-PEG1-NHS ester

m-PEG1-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

m-PEG1-NHS ester Chemical Structure

m-PEG1-NHS ester Chemical Structure

CAS No. : 1027371-75-0

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50 mg USD 35 In-stock
100 mg USD 57 In-stock
250 mg USD 112 In-stock
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Based on 1 publication(s) in Google Scholar

m-PEG1-NHS ester Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

m-PEG1-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG1-NHS ester Related Antibodies
Molecular Weight

201.18

Formula

C8H11NO5
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

COCCC(ON1C(CCC1=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (165.67 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9707 mL 24.8534 mL 49.7067 mL
5 mM 0.9941 mL 4.9707 mL 9.9413 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (497.07 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9707 mL 24.8534 mL 49.7067 mL 124.2668 mL
5 mM 0.9941 mL 4.9707 mL 9.9413 mL 24.8534 mL
10 mM 0.4971 mL 2.4853 mL 4.9707 mL 12.4267 mL
15 mM 0.3314 mL 1.6569 mL 3.3138 mL 8.2845 mL
20 mM 0.2485 mL 1.2427 mL 2.4853 mL 6.2133 mL
25 mM 0.1988 mL 0.9941 mL 1.9883 mL 4.9707 mL
30 mM 0.1657 mL 0.8284 mL 1.6569 mL 4.1422 mL
40 mM 0.1243 mL 0.6213 mL 1.2427 mL 3.1067 mL
50 mM 0.0994 mL 0.4971 mL 0.9941 mL 2.4853 mL
60 mM 0.0828 mL 0.4142 mL 0.8284 mL 2.0711 mL
80 mM 0.0621 mL 0.3107 mL 0.6213 mL 1.5533 mL
100 mM 0.0497 mL 0.2485 mL 0.4971 mL 1.2427 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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m-PEG1-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG1-NHS ester1027371-75-0PROTAC LinkersInhibitorinhibitorinhibit

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