2. PROTAC
  3. PROTAC Linkers
  4. Thiol-PEG4-alcohol

Thiol-PEG4-alcohol  (Synonyms: HS-PEG4-OH)

Cat. No.: HY-133292 Purity: ≥95.0%
COA Handling Instructions

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Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thiol-PEG4-alcohol Chemical Structure

Thiol-PEG4-alcohol Chemical Structure

CAS No. : 90952-27-5

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50 mg USD 75 In-stock
100 mg USD 118 In-stock
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Thiol-PEG4-alcohol Related Antibodies

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Description

Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thiol-PEG4-alcohol Related Antibodies
Molecular Weight

210.29

Formula

C8H18O4S
CAS No.
Appearance

Liquid

Color

Light brown to brown

SMILES

SCCOCCOCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (475.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7553 mL 23.7767 mL 47.5534 mL
5 mM 0.9511 mL 4.7553 mL 9.5107 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (239 KB) HNMR (129 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7553 mL 23.7767 mL 47.5534 mL 118.8835 mL
5 mM 0.9511 mL 4.7553 mL 9.5107 mL 23.7767 mL
10 mM 0.4755 mL 2.3777 mL 4.7553 mL 11.8883 mL
15 mM 0.3170 mL 1.5851 mL 3.1702 mL 7.9256 mL
20 mM 0.2378 mL 1.1888 mL 2.3777 mL 5.9442 mL
25 mM 0.1902 mL 0.9511 mL 1.9021 mL 4.7553 mL
30 mM 0.1585 mL 0.7926 mL 1.5851 mL 3.9628 mL
40 mM 0.1189 mL 0.5944 mL 1.1888 mL 2.9721 mL
50 mM 0.0951 mL 0.4755 mL 0.9511 mL 2.3777 mL
60 mM 0.0793 mL 0.3963 mL 0.7926 mL 1.9814 mL
80 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.4860 mL
100 mM 0.0476 mL 0.2378 mL 0.4755 mL 1.1888 mL
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Thiol-PEG4-alcohol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiol-PEG4-alcohol90952-27-5HS-PEG4-OHPROTAC LinkersInhibitorinhibitorinhibit

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