PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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Sulfo DBCO-amine
0 ImagesCat. No.: HY-127056CAS No.: 2028284-70-8
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Azido-PEG4-Thiol
0 ImagesCat. No.: HY-138525CAS No.: 2720615-82-5Azido-PEG4-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-Thiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Fmoc-Lys-OH hydrochloride
0 ImagesFmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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Methyl 1-Boc-azetidine-3-carboxylate
0 ImagesMethyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
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6-Maleimidocaproic acid sulfo-NHS sodium
0 ImagesCat. No.: HY-136158ACAS No.: 215312-86-0Synonyms: Sulfo-EMCS
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Tos-PEG3
0 ImagesCat. No.: HY-23408CAS No.: 77544-68-4
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HS-PEG3-CH2CH2NH2 hydrochloride
0 ImagesCat. No.: HY-130871ASynonyms: Thiol-PEG3-amine hydrochloride
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Bromoacetamido-PEG4-acid
0 ImagesCat. No.: HY-141382CAS No.: 1807518-67-7Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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5-Bromopentanoic acid
0 Images5-Bromopentanoic acid can be used for the synthesis of inhibitors for aminoglycoside resistant bacteria.
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Diethylene glycol bis(p-toluenesulfonate)
0 ImagesSynonyms: Diethylene glycol di(p-toluenesulfonate); Bis-Tos-PEG2
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Ald-CH2-PEG4-Boc
0 ImagesCat. No.: HY-140630CAS No.: 1415329-20-2
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Thiol-PEG2-acid
0 ImagesCat. No.: HY-138524CAS No.: 1379649-73-6
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DBCO-PEG4-alcohol
0 ImagesCat. No.: HY-140279CAS No.: 1416711-60-8
