2. PROTAC
  3. PROTAC Linkers
  4. Tos-PEG3

Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports.

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Tos-PEG3 Chemical Structure

Tos-PEG3 Chemical Structure

CAS No. : 77544-68-4

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Based on 1 publication(s) in Google Scholar

Tos-PEG3 Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tos-PEG3 Related Antibodies
Molecular Weight

304.36

Formula

C13H20O6S
CAS No.
Appearance

Solid-Liquid Mixture

Color

Colorless to light yellow

SMILES

OCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (328.56 mM; Need ultrasonic)

DMSO : 100 mg/mL (328.56 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 10 mg/mL (32.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2856 mL 16.4279 mL 32.8558 mL
5 mM 0.6571 mL 3.2856 mL 6.5712 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 16.67 mg/mL (54.77 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (243 KB) HNMR (233 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / Ethanol / DMSO 1 mM 3.2856 mL 16.4279 mL 32.8558 mL 82.1396 mL
5 mM 0.6571 mL 3.2856 mL 6.5712 mL 16.4279 mL
10 mM 0.3286 mL 1.6428 mL 3.2856 mL 8.2140 mL
15 mM 0.2190 mL 1.0952 mL 2.1904 mL 5.4760 mL
20 mM 0.1643 mL 0.8214 mL 1.6428 mL 4.1070 mL
25 mM 0.1314 mL 0.6571 mL 1.3142 mL 3.2856 mL
30 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.7380 mL
Ethanol / DMSO 40 mM 0.0821 mL 0.4107 mL 0.8214 mL 2.0535 mL
50 mM 0.0657 mL 0.3286 mL 0.6571 mL 1.6428 mL
60 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3690 mL
80 mM 0.0411 mL 0.2053 mL 0.4107 mL 1.0267 mL
100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8214 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tos-PEG3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tos-PEG377544-68-4PROTAC LinkersprotaclinkersolidsupportInhibitorinhibitorinhibit

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