2. PROTAC
  3. PROTAC Linkers
  4. Diethylene glycol bis(p-toluenesulfonate)

Diethylene glycol bis(p-toluenesulfonate)  (Synonyms: Diethylene glycol di(p-toluenesulfonate); Bis-Tos-PEG2)

Cat. No.: HY-W010948 Purity: 99.44%
COA Handling Instructions

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Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Diethylene glycol bis(p-toluenesulfonate) Chemical Structure

Diethylene glycol bis(p-toluenesulfonate) Chemical Structure

CAS No. : 7460-82-4

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Based on 1 publication(s) in Google Scholar

Diethylene glycol bis(p-toluenesulfonate) Related Antibodies

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Description

Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diethylene glycol bis(p-toluenesulfonate) Related Antibodies
Molecular Weight

414.49

Formula

C18H22O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(C)C=C1)(OCCOCCOS(C2=CC=C(C)C=C2)(=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (241.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4126 mL 12.0630 mL 24.1260 mL
5 mM 0.4825 mL 2.4126 mL 4.8252 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.44%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4126 mL 12.0630 mL 24.1260 mL 60.3151 mL
5 mM 0.4825 mL 2.4126 mL 4.8252 mL 12.0630 mL
10 mM 0.2413 mL 1.2063 mL 2.4126 mL 6.0315 mL
15 mM 0.1608 mL 0.8042 mL 1.6084 mL 4.0210 mL
20 mM 0.1206 mL 0.6032 mL 1.2063 mL 3.0158 mL
25 mM 0.0965 mL 0.4825 mL 0.9650 mL 2.4126 mL
30 mM 0.0804 mL 0.4021 mL 0.8042 mL 2.0105 mL
40 mM 0.0603 mL 0.3016 mL 0.6032 mL 1.5079 mL
50 mM 0.0483 mL 0.2413 mL 0.4825 mL 1.2063 mL
60 mM 0.0402 mL 0.2011 mL 0.4021 mL 1.0053 mL
80 mM 0.0302 mL 0.1508 mL 0.3016 mL 0.7539 mL
100 mM 0.0241 mL 0.1206 mL 0.2413 mL 0.6032 mL
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Diethylene glycol bis(p-toluenesulfonate) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diethylene glycol bis(p-toluenesulfonate)7460-82-4Diethylene glycol di(p-toluenesulfonate) Bis-Tos-PEG2PROTAC LinkersInhibitorinhibitorinhibit

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