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AA92593 

Cat. No.: HY-125145 Purity: 99.27%
Handling Instructions

AA92593 is a selective and competitive OPN4 (melanopsin) antagonist.

For research use only. We do not sell to patients.

AA92593 Chemical Structure

AA92593 Chemical Structure

CAS No. : 457961-34-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AA92593 is a selective and competitive OPN4 (melanopsin) antagonist[1][2].

In Vitro

AA92593 is a competitive melanopsin antagonist, its presence in the retinal-binding pocket of melanopsin leads to the displacement of retinal, which could trigger a downstream signaling that would ultimately result in Per1 increased expression[1].
AA92593 is shown to be specific because it competes with retinaldehyde for the melanopsin retinal binding site which is very distinct from other opsins[1].
Inhibition of melanopsin activity with AA92593 increases a-MSH expression and induces melanin dispersion in the melanophores, which darkens the embryo[3].
AA92593 exhibits an IC50 of 665 nM in CHOOpn4 cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Melan-a melanocytes and B16-F10 melanoma cells[1].
Concentration: 10 μM.
Incubation Time: 1 hour (heat 39.5 °C).
Result: Pharmacologically inhibited melanopsin.
In Vivo

AA92593 is able to decrease IOP in rabbits living under normal light condition[2].
AA92593 produces an increment in melatonin levels resulting in a drop of IOP[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type (WT) mice[4].
Dosage: 30 mg/kg.
Administration: IP 20 min prior to PLR measurement.
Result: Attenuated pupil constriction in response to light (1013 ph.cm−2.s−1) by ~50%.
Molecular Weight

269.36

Formula

C₁₃H₁₉NO₃S

CAS No.
SMILES

O=S(N1CCCCC1)(C2=CC=C(OC)C(C)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (928.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7125 mL 18.5625 mL 37.1250 mL
5 mM 0.7425 mL 3.7125 mL 7.4250 mL
10 mM 0.3713 mL 1.8563 mL 3.7125 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.72 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AA92593AA 92593AA-92593OthersOPN4MelanopsinMelanomaCHOα-MSHPer1Inhibitorinhibitorinhibit

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Product Name:
AA92593
Cat. No.:
HY-125145
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