2. Others Immunology/Inflammation
  3. Drug Intermediate Interleukin Related
  4. Anti-inflammatory agent 89

Anti-inflammatory agent 89 is a multi-target glucocorticoid-isothiocyanate hybrid with anti-inflammatory activity. Anti-inflammatory agent 89 releases hydrogen sulfide via its isothiocyanate group, inhibits antigen-induced mast cell degranulation, alleviates pulmonary inflammation, and suppresses bronchial hyperresponsiveness and airway fibrosis. Anti-inflammatory agent 89 can be used in asthma research.

For research use only. We do not sell to patients.

Anti-inflammatory agent 89

Anti-inflammatory agent 89 Chemical Structure

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Anti-inflammatory agent 89 Related Antibodies

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Description

Anti-inflammatory agent 89 is a multi-target glucocorticoid-isothiocyanate hybrid with anti-inflammatory activity. Anti-inflammatory agent 89 releases hydrogen sulfide via its isothiocyanate group, inhibits antigen-induced mast cell degranulation, alleviates pulmonary inflammation, and suppresses bronchial hyperresponsiveness and airway fibrosis. Anti-inflammatory agent 89 can be used in asthma research[1].

IC50 & Target[1]

IL-13

 

In Vitro

Anti-inflammatory agent 89 (compound 5c) (200 μM; up to 4 h) shows moderate enzymatic stability in BSA medium, with a half-life of 1.4 h, and releases its parent glucocorticoid upon metabolism[1].
Anti-inflammatory agent 89 acts as a slow, sustained H2S donor in a cell-free environment[1].
Anti-inflammatory agent 89 (100 μM; 24 h) is non-cytotoxic to RBL-2H3 mast cells[1].
Anti-inflammatory agent 89 (100 μM; 5 min prior to 1 h degranulation stimulus) potently inhibits antigen-induced degranulation of RBL-2H3 mast cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 89 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: RBL-2H3 mast cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Did not reduce cell viability compared to the vehicle.
In Vivo

Anti-inflammatory agent 89 (compound 5c) (1-2 mg/kg; i.p.; 2 doses (30 minutes before ovalbumin sensitization on days 0 and 7)) inhibits ovalbumin-induced asthma features in female BALB/c mice in vivo in a dose-dependent manner, with the 2 mg/kg dose fully restoring bronchial reactivity, reducing airway fibrosis, improving pulmonary structure, and lowering plasma IgE and pulmonary IL-13 levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 8 weeks old, 20 g, ovalbumin-induced asthma model)[1]
Dosage: 1 mg/kg; 2 mg/kg
Administration: i.p.; 2 doses (30 minutes before ovalbumin sensitization on days 0 and 7)
Result: Mitigated carbachol-induced bronchial hyperreactivity at 1 mg/kg, without complete recovery of pulmonary architecture or elimination of lung inflammation.
Normalized bronchial reactivity to baseline values at 2 mg/kg.
Lessened α-SMA-positive muscular layer thickness at 2 mg/kg, indicating alleviated airway fibrosis.
Recovered intact lung structure at 2 mg/kg via eliminating cellular infiltration, smooth muscle hyperplasia and lamina propria detachment.
Lowered plasma IgE concentrations markedly at 2 mg/kg.
Diminished pulmonary IL-13 contents in a dose-responsive fashion.
Molecular Weight

569.71

Formula

C31H39NO7S
SMILES

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H]5[C@@]4(C(COC(CSC#N)=O)=O)O[C@]([H])(C6CCCCC6)O5)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 89 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 89Drug IntermediateInterleukin RelatedDrug IintermediateILmast cell degranulationasthmaRBL-2H3 mast cellshydrogen sulfidefemale BALB/c miceIL-13lung inflammationovalbuminbronchial hyperreactivityairway fibrosisInhibitorinhibitorinhibit

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