2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Anticancer agent 207

Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a KD value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity.

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Anticancer agent 207

Anticancer agent 207 Estructura química

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Anticancer agent 207 Related Antibodies

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Descripciòn

Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a KD value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity[1].

IC50 & Target[1]

NRAS rG4

2.31 μM (Kd)

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
4.5 μM
Compound: 10b
Cytotoxicity against human A-375 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human A-375 cells incubated for 48 hrs by MTT assay
[PMID: 38688064]
HepG2 IC50
1.5 μM
Compound: 10b
Cytotoxicity against human HepG2 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 48 hrs by MTT assay
[PMID: 38688064]
HL-60 IC50
2.7 μM
Compound: 10b
Cytotoxicity against human HL-60 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HL-60 cells incubated for 48 hrs by MTT assay
[PMID: 38688064]
MCF7 IC50
4.1 μM
Compound: 10b
Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay
[PMID: 38688064]
SK-MEL-2 IC50
2 μM
Compound: 10b
Cytotoxicity against human SK-MEL-2 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human SK-MEL-2 cells incubated for 48 hrs by MTT assay
[PMID: 38688064]
In Vitro

Anticancer agent 207 (48 h) shows cytotoxicity for NRAS-mutant melanoma SK-MEL-2 with an IC50 value of 2.0 µM[1].
Anticancer agent 207 (0, 0.5, 1.0 µM; 72 h) decreases the expression of NRAS protein[1].
Anticancer agent 207 (0, 0.13, 0.25 µM; 10 days) inhibits the colony formation of SK-MEL-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 207 Related Antibodies

Western Blot Analysis[1]

Cell Line: SK-MEL-2 cells
Concentration: 0, 0.5, 1.0 µM
Incubation Time: 72 h
Result: Decreased the expression of NRAS protein in a dose-dependent manner.

Cell Proliferation Assay[1]

Cell Line: MCF-7, HepG2, HL60, A375 cells
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Showed cytotoxicity with IC50s of 4.1, 1.5, 2.7, 4.5 µM for MCF-7, HepG2, HL60, A375 cells, respectively.
In Vivo

Anticancer agent 207 (1 mg/kg; i.p.; every day for 21 days) inhibits tumor growth in volume and weight in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male BALB/C nude mice (SK-MEL-2 xenograft mouse model)[1]
Dosage: 1 mg/kg
Administration: I.p.; every day for 21 days
Result: Suppressed tumor growth in volume and weight in the xenograft mouse model time-dependently.
Peso molecular

494.64

Fòrmula

C29H39FN4O2
SMILES

CCCCN(CCCOC1=CC=C2N=C3C4=C(OC3=C(C2=C1)NCCCN)C=CC(F)=C4)CCCC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Anticancer agent 207 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 207Anticancer agent207Anticancer agent-207RasmelanomacytotoxicitySK-MEL-2 cellsantitumorNRAS rG4Inhibitorinhibitorinhibit

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Anticancer agent 207
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