Adrenalone hydrochloride
Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM.
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- Reinheit: 99.88%
- CAS. Nr.: 62-13-5
- Formel: C9H12ClNO3
- Molecular Weight:217.65
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Speicherung:
4°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Adrenalone hydrochlorideis a topical nasal decongestant, hemostatic, and vasoconstrictor, is a keton form of the natural substrate epinephrine[1].
Adrenalone hydrochloride inhibits the activity of dopamine β-oxidase. Adrenalone inhibits substrate transport by NET[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 62-13-5
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Appearance Solid
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Molecular Weight 217.65
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Formel C9H12ClNO3
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Color Light yellow to yellow
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SMILES
CNCC(C1=CC=C(O)C(O)=C1)=O.[H]Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (459.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (229.73 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.49 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.49 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. M GOLDSTEIN,et al. Inhibition of dopamine beta oxidase by adrenalone. Nature.1961 Dec 16;192:1081. [Content Brief]
[2]. Avner Schlessinger, et al. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15810-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 4.5945 mL | 22.9727 mL | 45.9453 mL | 114.8633 mL |
| 5 mM | 0.9189 mL | 4.5945 mL | 9.1891 mL | 22.9727 mL | |
| 10 mM | 0.4595 mL | 2.2973 mL | 4.5945 mL | 11.4863 mL | |
| 15 mM | 0.3063 mL | 1.5315 mL | 3.0630 mL | 7.6576 mL | |
| 20 mM | 0.2297 mL | 1.1486 mL | 2.2973 mL | 5.7432 mL | |
| 25 mM | 0.1838 mL | 0.9189 mL | 1.8378 mL | 4.5945 mL | |
| 30 mM | 0.1532 mL | 0.7658 mL | 1.5315 mL | 3.8288 mL | |
| 40 mM | 0.1149 mL | 0.5743 mL | 1.1486 mL | 2.8716 mL | |
| 50 mM | 0.0919 mL | 0.4595 mL | 0.9189 mL | 2.2973 mL | |
| 60 mM | 0.0766 mL | 0.3829 mL | 0.7658 mL | 1.9144 mL | |
| 80 mM | 0.0574 mL | 0.2872 mL | 0.5743 mL | 1.4358 mL | |
| 100 mM | 0.0459 mL | 0.2297 mL | 0.4595 mL | 1.1486 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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