BPAM363
BPAM363 is an orally active, selective positive allosteric modulator (PAM) of AMPARs with blood-brain barrier penetration. BPAM363 selectively potentiates AMPAR activity in human and rat models, with an EC2x value of 0.96 μM in rat embryonic cortex primary neurons. BPAM363 upregulates BDNF protein expression in rat primary cortical neuronal cultures. BPAM363 enhances AMPA-mediated excitatory postsynaptic responses in rat and mice. BPAM363 can be used for the study of cognitive disorders.
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- CAS. Nr.: 1204572-46-2
- Formel: C10H10Cl2N2O2S
- Molecular Weight:293.17
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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AMPA Receptor |
BPAM363 (Compound 14o) exerts AMPA receptor-potentiating activity in primary cultures of neurons from rat embryonic cortex, with an EC2x value of 0.96 μM[1].
BPAM363 enhances AMPA-evoked inward current in Xenopus laevis oocytes injected with rat cortex or human hippocampus poly(AM+) mRNA (rat cortex mRNA: EC50 = 9.9 μM; human hippocampus mRNA: EC50 = 18 μM)[1].
BPAM363 (3-30 μM) modulates AMPA-mediated excitatory postsynaptic responses in the CA1 area of rat hippocampal slices through enhancing the response area[1].
BPAM363 (0.3-10 μM, 24 h) upregulates BDNF protein expression in rat primary cortical neuronal cultures in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult Wistar rats, Adult CD1 mice and Adult C57BI/6 mice[1]
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Dosage:0.01, 0.03, 1, 3, 10, 30 mg/kg
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Administration:i.p., single dose
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Result:Enhanced the induction and maintenance of long-term potentiation (LTP) in the dentate gyrus (10, 30 mg/kg).
Improved episodic memory in CD1 mice (1, 3 mg/kg).
Enhanced spatial working memory in C57BI/6 mice (0.01, 0.03 mg/kg).
Exertd neuroprotective effects in Wistar rats with transient global cerebral ischemia (10mg/kg).
Chemical Information
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CAS. Nr. 1204572-46-2
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Molecular Weight 293.17
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Formel C10H10Cl2N2O2S
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SMILES
O=S1(NCN(C2=CC(Cl)=C(C=C21)Cl)C3CC3)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Lesenfants C, et al. Structural Exploration around 4-Cyclopropyl-Substituted 1,2,4-Benzothiadiazine 1,1-Dioxides: Impact of the Dihalo-Substitution of the Benzene Ring on α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptor Potentiation. J Med Chem. 2025 Sep 11;68(17):18641-18659. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BPAM363 Related Classifications
HY-178153 Related Classifications
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