Agt - angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Gene

Also Known as AngI; AngII; Aogen; Serpina8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11606

Summary

Enables type 1 Angiotensin Receptor binding activity and type 2 Angiotensin Receptor binding activity. Involved in positive regulation of cytokine production. Acts upstream of or within several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (Angiotensinogen). [provided by Alliance of Genome Resources, Apr 2022]

Agt Products (1)

mRNA Protein Name
NM_007428.4 NP_031454.4 angiotensinogen precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables type 1 angiotensin receptor binding IDA
IDA: Inferred from direct assay
9878677 MGI
enables type 2 angiotensin receptor binding IPI
IPI: Inferred from physical interaction
9878677 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
9196031 MGI
acts upstream of or within aldosterone secretion IMP
IMP: Inferred from mutant phenotype
9557921 MGI
involved in aldosterone secretion IMP
IMP: Inferred from mutant phenotype
22550170 MGI
acts upstream of or within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IDA
IDA: Inferred from direct assay
10425188 MGI
acts upstream of or within astrocyte activation IMP
IMP: Inferred from mutant phenotype
9734405 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
8675666 MGI
acts upstream of or within brain renin-angiotensin system IDA
IDA: Inferred from direct assay
9878677 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
12657564 MGI
NOT acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
8675666 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
8675666 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
9734405 MGI
acts upstream of or within drinking behavior IMP
IMP: Inferred from mutant phenotype
9852267 MGI
acts upstream of or within establishment of blood-nerve barrier IMP
IMP: Inferred from mutant phenotype
9734405 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
9734405 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
12660889 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
8675666 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11606482 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9310306 MGI
acts upstream of or within negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
8675666 MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
8675666 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9310306 MGI
acts upstream of organ growth IDA
IDA: Inferred from direct assay
16374517 MGI
acts upstream of or within ovarian follicle rupture IMP
IMP: Inferred from mutant phenotype
11384650 MGI
acts upstream of or within peristalsis IMP
IMP: Inferred from mutant phenotype
9788961 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
9196031 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
19404405 MGI
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
19023134 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
34615811 MGI
acts upstream of or within positive regulation of fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
11606482 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
19404405 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
12660889 MGI
acts upstream of or within positive regulation of organ growth IDA
IDA: Inferred from direct assay
16374517 MGI
acts upstream of or within positive regulation of organ growth IMP
IMP: Inferred from mutant phenotype
12660889 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
23775122 MGI
acts upstream of or within positive regulation of protein kinase C activity IDA
IDA: Inferred from direct assay
23775122 MGI
acts upstream of or within regulation of apoptotic process IDA
IDA: Inferred from direct assay
19404405 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
9557921 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
16585392 MGI
acts upstream of or within regulation of inflammatory response IDA
IDA: Inferred from direct assay
19404405 MGI
acts upstream of or within regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
19404405 MGI
acts upstream of or within regulation of renal output by angiotensin IMP
IMP: Inferred from mutant phenotype
9507198 MGI
acts upstream of or within regulation of systemic arterial blood pressure by circulatory renin-angiotensin IMP
IMP: Inferred from mutant phenotype
7989296 MGI
acts upstream of or within renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
11606482 MGI
acts upstream of or within renin-angiotensin regulation of aldosterone production IMP
IMP: Inferred from mutant phenotype
9852267 MGI
acts upstream of or within response to cold IMP
IMP: Inferred from mutant phenotype
12574102 MGI
acts upstream of or within response to salt stress IMP
IMP: Inferred from mutant phenotype
9557921 MGI
acts upstream of or within smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
9788961 MGI
acts upstream of or within smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
9788961 MGI
acts upstream of or within smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
9788961 MGI
acts upstream of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
8675666 MGI
acts upstream of or within smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
9788961 MGI
acts upstream of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
8675666 MGI
acts upstream of or within vasopressin secretion IMP
IMP: Inferred from mutant phenotype
9557921 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
7989296 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiotensinogen

  • angiotensin I

  • angiotensin ll

  • serpin A8

Recombinant Agt Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P73652 Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) P11859 (D25-V477) ≥ 95%, as determined by reducing SDS-PAGE.

Agt Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82352 Angiotensinogen Antibody (YA2097) WB, IHC-P, IP Mouse
HY-P82352A Angiotensinogen Antibody (YA2097)(PBS only) WB, IHC-P, IP Mouse

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-108764 Mipomersen sodium Inhibitor 95.60% Phase 3
HY-W002585 O6-Benzylguanine 99.92% Phase 3
HY-143230 Custirsen Inducer 96.12% Phase 3
HY-145649A Zilebesiran sodium / Phase 2
Inhibitory Antibodies (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99530 Valanafusp alfa 98.42% Phase 2
HY-P992048 AGT-182 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-150738 ODN 2088 Antagonist 98.82% Unkown
HY-148413 Aprinocarsen sodium Inhibitor 98.42% Unkown
HY-150736 ODN 20844 Inhibitor 96.14% Unkown
HY-145649 Zilebesiran 95.63% Unkown
HY-150744 ODN 24888 Inhibitor / Unkown
HY-106435 Cystemustine Inhibitor / Unkown
HY-147406 Tonlamarsen / Unkown
HY-150740 ODN 21595 Inhibitor / Unkown
HY-186228 Anticancer agent 333 / Unkown
HY-D2935 CoDi2 / Unkown
HY-D2981 CoDi1 / Unkown
HY-D2995 CoDi3 / Unkown
HY-P5939 Angiotensinogen (1-13) (human) / Unkown
HY-RS00466 AGT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00473 AGXT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08412 Mgmt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-19932 MK-2748 Inhibitor / Unkown
HY-RS17726 Agt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24191 Agt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Agt NCBI NCBI:183