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Angiotensinogen Antibody (YA2097)(PBS only)

(Synonyms: Angiotensinogen; Serpin A8; AGT; SERPINA8; Des-Asp[1]-angiotensin II; Serine (or cysteine) proteinase inhibitor)

Angiotensinogen Antibody (YA2097) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Angiotensinogen.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, IP

  • Reactivity :

    Mouse

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for Angiotensinogen Antibody (YA2097)(PBS only)
  • Angiotensinogen Antibody (YA2097)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:50-1:100 1:20

Product Details

Description

Angiotensinogen Antibody (YA2097) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Angiotensinogen.

  • Host Rabbit
  • Species Reactivity
    Mouse
  • Observed Molecular Weight
    Observed band size: 52 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 52 kDa
Immunogen

Recombinant protein of mouse Angiotensinogen full length.

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for Angiotensinogen Antibody (YA2097)(PBS only)
    Western blot analysis of extracts from Mouse Brain (lane 2(20μg)) and Mouse Heart (lane 3(10μg)) using Angiotensinogen Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (GAPDH, HY-P80954, 1/5000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit/Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

  • Function

    Angiotensinogen is essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2. Also binds the DEAR/FBXW7-AS1 receptor; Stimulates aldosterone release; Is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets[1][2].

  • Subcellular Localization

    Secreted

  • SwissProt ID

    P11859

  • Gene ID
    11606 [NCBI]
  • Synonyms

    Angiotensinogen; Serpin A8; AGT; SERPINA8; Des-Asp[1]-angiotensin II; Serine (or cysteine) proteinase inhibitor

  • Research Field

    Cardiovascular

Angiotensinogen Antibody (YA2097)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from Mouse Brain (lane 2(20μg)) and Mouse Heart (lane 3(10μg)) using Angiotensinogen Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (GAPDH, HY-P80954, 1/5000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit/Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • Angiotensinogen Antibody (YA2097)(PBS only) Product Image
    1/16
  • Experimental Validation Results for Angiotensinogen Antibody (YA2097)(PBS only)
  • Angiotensinogen Antibody (YA2097)(PBS only) Product Image
  • Experimental Validation Results for Angiotensinogen Antibody (YA2097)(PBS only)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from Mouse Brain (lane 2(20μg)) and Mouse Heart (lane 3(10μg)) using Angiotensinogen Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (GAPDH, HY-P80954, 1/5000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit/Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
  • Experimental Validation Results for Angiotensinogen Antibody (YA2097)(PBS only)
  • Angiotensinogen Antibody (YA2097)(PBS only) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from Mouse Brain (lane 2(20μg)) and Mouse Heart (lane 3(10μg)) using Angiotensinogen Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (GAPDH, HY-P80954, 1/5000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit/Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • Angiotensinogen Antibody (YA2097)(PBS only) Product Image WB