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Srf - serum response factor Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20807

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and nucleic acid binding activity. Involved in actin Cytoskeleton organization and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and generation of neurons. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including blastocyst; branchial arch; future forebrain; genitourinary system; and salivary gland. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor). [provided by Alliance of Genome Resources, Apr 2022]

Srf Products (1)

mRNA	Protein	Name
NM_020493.2	NP_065239.1	serum response factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	21098124	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11439182	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8900044	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21379568	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8900044	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	11278942	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11439182	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	18458156	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	21379568	MGI
enables primary miRNA binding	IDA IDA: Inferred from direct assay	21303526	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11278942	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20534669	MGI
enables serum response element binding	IDA IDA: Inferred from direct assay	2062642	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	24732378	MGI
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15837932	MGI
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	18804439	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	16600861	MGI
acts upstream of axon extension	IMP IMP: Inferred from mutant phenotype	24623780	MGI
acts upstream of or within bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	20047077	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	18804439	MGI
acts upstream of or within bronchus cartilage development	IMP IMP: Inferred from mutant phenotype	24218621	MGI
involved in cardiac muscle cell myoblast differentiation	IGI IGI: Inferred from genetic interaction	19783823	MGI
acts upstream of or within cardiac myofibril assembly	IMP IMP: Inferred from mutant phenotype	15569937	MGI
acts upstream of or within cardiac vascular smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	15569937	MGI
acts upstream of or within cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	18804439	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	21401944	MGI
acts upstream of or within cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	20525922	MGI
acts upstream of or within contractile actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	15569937	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	9799237	MGI
acts upstream of or within dorsal aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	15569937	MGI
acts upstream of or within epithelial cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20047077	MGI
acts upstream of or within epithelial structure maintenance	IMP IMP: Inferred from mutant phenotype	20047077	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	20709909	MGI
acts upstream of or within establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	20047077	MGI
acts upstream of or within eyelid development in camera-type eye	IMP IMP: Inferred from mutant phenotype	20047077	MGI
acts upstream of or within face development	IMP IMP: Inferred from mutant phenotype	18952847	MGI
acts upstream of filopodium assembly	IMP IMP: Inferred from mutant phenotype	18804439	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	20534669	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	9799237	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15169892	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	15929941	MGI
acts upstream of or within heart trabecula formation	IMP IMP: Inferred from mutant phenotype	15569937	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20709909	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	15837932	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9799237	MGI
acts upstream of or within leukocyte differentiation	IMP IMP: Inferred from mutant phenotype	20709909	MGI
acts upstream of or within long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	16600861	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	24218621	MGI
acts upstream of or within lung smooth muscle development	IMP IMP: Inferred from mutant phenotype	24218621	MGI
acts upstream of or within megakaryocyte development	IMP IMP: Inferred from mutant phenotype	20525922	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	9799237	MGI
acts upstream of or within morphogenesis of an epithelial sheet	IMP IMP: Inferred from mutant phenotype	20047077	MGI
acts upstream of or within muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	15647354	MGI
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	21303526	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	15837932	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	19357276	MGI
acts upstream of or within platelet activation	IMP IMP: Inferred from mutant phenotype	20525922	MGI
acts upstream of or within platelet formation	IMP IMP: Inferred from mutant phenotype	20525922	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20534669	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19797053	MGI
acts upstream of or within positive regulation of axon extension	IGI IGI: Inferred from genetic interaction	24623780	MGI
acts upstream of or within positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	24623780	MGI
acts upstream of or within positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	18804439	MGI
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	19578358	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8900044	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12732141	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16510470	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15929941	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	21098124	MGI
acts upstream of or within primitive streak formation	IMP IMP: Inferred from mutant phenotype	9799237	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12525493	MGI
acts upstream of or within regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	18804439	MGI
acts upstream of or within sarcomere organization	IMP IMP: Inferred from mutant phenotype	15569937	MGI
acts upstream of or within skin morphogenesis	IMP IMP: Inferred from mutant phenotype	20047077	MGI
acts upstream of or within stress fiber assembly	IMP IMP: Inferred from mutant phenotype	20525922	MGI
acts upstream of or within tangential migration from the subventricular zone to the olfactory bulb	IMP IMP: Inferred from mutant phenotype	15837932	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	18952847	MGI
acts upstream of or within thyroid gland development	IMP IMP: Inferred from mutant phenotype	18952847	MGI
acts upstream of or within trachea cartilage development	IMP IMP: Inferred from mutant phenotype	24218621	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18511849	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15929941	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in chromatin	IDA IDA: Inferred from direct assay	16427017	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17576768	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15929941	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serum response factor

Srf Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Srf	Q9JM73	Srebf2	Mus musculus	Q3U1N2	Y2H	15102471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P990068	Perenostobart	Inhibitor	97.00%	Phase 2
HY-P990024	Casdozokitug	Inhibitor	96.49%	Phase 2
HY-P99533	Urabrelimab	Inhibitor	99.487%	Phase 1
HY-P991061	Tagmokitug	Inhibitor	99.9%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-13991	CCG-1423		99.88%	Unkown
HY-108361	CCG-203971	Inhibitor	99.89%	Unkown
HY-120855	CCG-100602	Inhibitor	99.29%	Unkown
HY-132187	Sphingosylphosphorylcholine		99.50%	Unkown
HY-111432	CCG-232601	Inhibitor	99.00%	Unkown
HY-162904	BPU17		98.16%	Unkown
HY-118748	Suprafenacine	Inhibitor	98.0%	Unkown
HY-153078	MRTF/SRF-IN-1	Inhibitor	99.68%	Unkown
HY-130011	CCG-232964	Inhibitor	/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-RS13760	SRF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17529	Srf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23985	Srf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srf	NCBI	NCBI:6722