Ilicicolin H
Based on 1 Customer Validation
Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.7%
- CAS. Nr.: 12689-26-8
- Formel: C27H31NO4
- Molecular Weight:433.54
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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PGK1 9.02 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
13.84 μM
Compound: 10
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Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| A549 | IC50 |
7.01 μM
Compound: 10
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| B16-F10 | IC50 |
21.58 μM
Compound: 10
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Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| CT26 | IC50 |
19.54 μM
Compound: 10
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Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| HCT-116 | IC50 |
10.75 μM
Compound: 10
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| MC-38 | IC50 |
19.55 μM
Compound: 10
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Cytotoxicity against mouse MC38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse MC38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| MDA-MB-231 | IC50 |
9.98 μM
Compound: 10
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| MDA-MB-435 | IC50 |
6.34 μM
Compound: 10
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Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| NCI-H1703 | IC50 |
6.65 μM
Compound: 10
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Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| PC-3 | IC50 |
>50 μM
Compound: 10
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
| SNB-19 | IC50 |
14.59 μM
Compound: 10
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Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38527379] |
Ilicicolin H (1-8 μM, 24 h) induces apoptosis and increases active cleaved fragments of Caspase-3, Caspase-9 levels in HepG2 and Huh7 cells[1].
Ilicicolin H (2-8 μM, 6 h) reduces the levels of HIF-1α induced by CoCl 2 and the phosphorylation levels of PDHK1 at T338 induced by EGF in HepG2 cells[1].
Ilicicolin H (1-8 μM, 6 h) inhibits lactate production and glucose uptake in HepG2 cells[1].
Ilicicolin H shows anti-fungal activity against C. albicans (0.04 to 0.31 μg/mL), other Candida species (0.01 to 5.0 μg/mL), Cryptococcus (MIC = 0.1-1.56 μg/mL) and A. fumigatus (MIC = 0.08 μg/mL)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 and Huh7 cells
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Concentration:1, 2, 4 and 8 μM
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Incubation Time:24 h
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Result:Increased C-Cas3, C-Cas9, and C-Parp levels.
Increased apoptotic cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C. albicans infected mice models[2]
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Dosage:6.25, 12.5, 25 and 50 mg/kg
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Administration:Orally administration, daily for 2 days
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Result:Reduced C. albicans burden.
Chemical Information
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CAS. Nr. 12689-26-8
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Appearance Solid
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Molecular Weight 433.54
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Formel C27H31NO4
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Color Light yellow to yellow
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SMILES
O=C1C(C([C@H]2[C@H](/C=C/C)[C@@]3([H])C[C@@H](C)CC[C@]3([H])C(C)=C2)=O)=C(O)C(C4=CC=C(O)C=C4)=CN1
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Structure Classification
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Initial Source
Campylocarpon sp.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Li M, et al. A novel inhibitor of PGK1 suppresses the aerobic glycolysis and proliferation of hepatocellular carcinoma. Biomed Pharmacother. 2023 Feb;158:114115. [Content Brief]
[2]. Singh SB, et al. Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h. ACS Med Chem Lett. 2012 Sep 7;3(10):814-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Ilicicolin H Related Classifications
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