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Art. -Nr.: HY-110092

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PSB-1114 tetrasodium

PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors.

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CAS. Nr.: 1657025-60-9
Formel: C₁₀H₁₁F₂N₂Na₄O₁₃P₃S
Molecular Weight:622.14

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

PSB-1114 tetrasodium Chemical Structure

CAS. Nr.: 1657025-60-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

EC50: 134 nM (P2Y₂ receptor), 9.3 μM (P2Y₄ receptor); 7.0 μM (P2Y₆ receptor)^[1]

Alle P2Y Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

PSB-1114 (4-Thio-β,γ-difluoromethylene-UTP; compound 14g) displays >60-fold selectivity versus P2Y4 and P2Y6 receptors. Because of its high potency, selectivity, and expected metabolic stability toward ectonucleotidases, in particular NTPDases, PSB-1114 may be a useful pharmacological tool for studying P2Y2 receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1657025-60-9
Molecular Weight 622.14
Formel C₁₀H₁₁F₂N₂Na₄O₁₃P₃S
SMILES

O[C@H]1[C@H](N2C(NC(C=C2)=S)=O)O[C@H](COP(OP(C(F)(F)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@H]1O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. El-Tayeb A, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90. [Content Brief]

[2]. Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors. Pharmacol Ther. 2018 Oct;190:24-80. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- IC₅₀ & Target
- In Vitro
Chemical Information
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PSB-1114 tetrasodium

Alle P2Y Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PSB-1114 tetrasodium Related Classifications

HY-110092 Related Classifications