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Art. -Nr.: HY-P99404

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Biologically Validated

Quetmolimab

(Synonyms: E6011)

Kundenbewertung

Based on 1 Customer Validation

Quetmolimab (E6011) is a humanized anti-Fractalkine (CX3CL1) monoclonal antibody. Quetmolimab binds to membrane-bound and soluble Fractalkine, neutralizes Fractalkine-induced migration of CX3CR1-expressing cells, mediates target-bound complex elimination from serum. Quetmolimab suppresses free soluble Fractalkine levels in cynomolgus monkeys, with target engagement linked to increased serum total Fractalkine concentration. Quetmolimab can be used for the research of Crohn’s disease, rheumatoid arthritis, and primary biliary cholangitis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.9%
CAS. Nr.: 2084037-83-0
Molecular Weight:144.72 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Quetmolimab Chemical Structure

CAS. Nr.: 2084037-83-0

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Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG2 kappa

Recommend Isotype Controls

Human IgG2 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CX3CL1/Fractalkine

Alle CXCR Isoform-spezifische Produkte anzeigen :

In Vitro

Quetmolimab (E6011) inhibits fractalkine-induced migration of human CX3CR1-transfected B300.19 mouse B-lymphocyte precursors, with a minimum active concentration of 3.2 ng/mL for 10% maximal suppression of free soluble FKN from baseline^[1].
Quetmolimab binds to soluble human fractalkine with a mean equilibrium dissociation constant of 0.27 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Quetmolimab (E6011) (0.05-100 mg/kg; i.v.; single infusion) at doses from 0.05 to 100 mg/kg in cynomolgus monkeys engages its target (fractalkine) as confirmed by increased total serum FKN concentrations, with a near-complete maximum effect (E_MAX = 0.974) on modulating free soluble FKN elimination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cynomolgus monkeys (median body weight 3.44 kg)^[1]
Dosage:

0.05-100 mg/kg
Administration:

i.v.; single infusion
Result:

Exhibited a triphasic elimination profile, with dose-dependent increases in exposure where area under the concentration-time curve (AUC) increased more than proportionally to dose.
Increased serum total FKN concentration, confirming target engagement.
Reached a maximum effect (EMAX) of 0.974, indicating near-complete suppression of free soluble FKN elimination at sufficient concentrations.

Gene ID

6376 [NCBI]

Accession

P78423

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG2 kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Fractalkine/CX3CL1 Protein, Human (HY-P7180) can bind Quetmolimab. The EC₅₀ for this effect is 3.65 ng/mL.

Chemical Information

CAS. Nr. 2084037-83-0
Appearance Liquid
Molecular Weight 144.72 kDa
Color Colorless to light yellow
SMILES

[Quetmolimab]
Synonyms

E6011
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Tabuchi H, et al. Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study. J Clin Pharmacol. 2019;59(5):688-701. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Quetmolimab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library

Alle CXCR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Quetmolimab Related Classifications

HY-P99404 Related Classifications