country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-165438

Copy Link Print Information

Sergliflozin-A

Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 360775-96-8
Formel: C₂₀H₂₄O₇
Molecular Weight:376.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Sergliflozin-A Chemical Structure

CAS. Nr.: 360775-96-8

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

SGLT1

SGLT2

Alle SGLT Isoform-spezifische Produkte anzeigen :

SGLT1
SGLT2

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	9.2 nM Compound: 4a	Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation	[PMID: 18260618]
CHO	EC₅₀	>8000 nM Compound: 4a	Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation	[PMID: 18260618]
CHO	IC₅₀	6.25 nM Compound: 6	Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting	[PMID: 20181486]
CHO	IC₅₀	2300 nM Compound: 3-active	Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins	[PMID: 21873071]
CHO	IC₅₀	4.8 nM Compound: 3-active	Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins	[PMID: 21873071]
CHO-K1	IC₅₀	2300 nM Compound: 2-A	Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay	[PMID: 22652255]
CHO-K1	IC₅₀	4.8 nM Compound: 2-A	Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay	[PMID: 22652255]

Chemical Information

CAS. Nr. 360775-96-8
Molecular Weight 376.40
Formel C₂₀H₂₄O₇
SMILES

COC(C=C1)=CC=C1CC(C=CC=C2)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and …

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Sergliflozin-A

High-Throughput Bioactive Compound Library

Alle SGLT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Sergliflozin-A Related Classifications

HY-165438 Related Classifications