Timolol hemimaleate
Based on 6 publication(s) in Google Scholar
Timolol ((S)-L-714,465; MK 950) hemimaleate is a β-blocker available for both topical and systemic administration. Topical Timolol hemimaleate is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol hemimaleate can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect.
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- CAS. Nr.: 33305-95-2
- Formel: C13H24N4O3S.1/2C4H4O4
- Molecular Weight:374.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Timolol hemimaleate
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Biologische Aktivität
Timolol hemimaleate can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol hemimaleate can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3-month old male Wistar rats[3].
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Dosage:5 mg/kg.
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Administration:Timolol (5 mg/kg daily for 12-week)
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Result:Showed cardioprotective effect.
Chemical Information
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CAS. Nr. 33305-95-2
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Molecular Weight 374.45
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Formel C13H24N4O3S.1/2C4H4O4
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SMILES
OC(/C=C\C(O)=O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N2CCOCC2.[1/2]
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Synonyms
(S)-L-714,465 hemimaleate; MK 950 hemimaleate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Mater
Colloid-Forming Prodrug-Hydrogel Composite Prolongs Lower Intraocular Pressure in Rodent Eyes after Subconjunctival Injection. [Abstract]2025 Jan 6:e2419306. PMID: 39763100 -
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Protein Cell
Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy. [Abstract]2019 Mar;10(3):178-195. PMID: 29542010 -
Redox Biol
2024 Dec 21:79:103481. PMID: 39721495 -
Mater Today Bio
Transdermal delivery of timolol maleate using hydrogel microneedles for the treatment of infantile haemangiomas. [Abstract]2025 Apr 12:32:101752. PMID: 40290897 -
Reinheit & Dokumentation
Verweise
[1]. James Barnes; Majid Moshirfar. Timolol.
[2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152. [Content Brief]
[3]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr. 2014 Oct;46(5):377-87. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Timolol hemimaleate Related Classifications
HY-17494B Related Classifications
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