1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Timolol

Timolol 

Cat. No.: HY-17494
Handling Instructions

Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect.

For research use only. We do not sell to patients.

Timolol Chemical Structure

Timolol Chemical Structure

CAS No. : 26839-75-8

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Description

Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].

In Vitro

Timolol can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Timolol has a cardioprotective effect via inhibition of ERS response in diabetic rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Experimental diabetes model: 3-month old male Wistar rats[3].
Dosage: 5 mg/kg
Administration: Timolol (5 mg/kg daily for 12-week)
Result: Showed cardioprotective effect.
Molecular Weight

316.42

Formula

C13H24N4O3S

CAS No.
SMILES

O[[email protected]](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Timolol
Cat. No.:
HY-17494
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