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Art. -Nr.: HY-178297

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VHR-IN-7

VHR-IN-7 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC₅₀ of 71 nM. VHR-IN-7 shows very weaker inhibitory activity against MKP-1 (IC₅₀ = 0.47 μM), CD45 (IC₅₀ = 0.3 μM), Cdc25A (IC₅₀ = 3.4 μM), PTP1B (IC₅₀ = 0.59 μM), and HePTP (IC₅₀ = 1.2 μM). VHR-IN-7 inhibits the proliferation of HeLa cells. VHR-IN-7 can be used for the research of cervical cancer.

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CAS. Nr.: 1146616-17-2
Formel: C₂₈H₂₂ClN₃O₅S₃
Molecular Weight:612.14

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

VHR-IN-7 Chemical Structure

CAS. Nr.: 1146616-17-2

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

VHR-IN-7 (Compound SA2) (20 μM, 24 h) inhibits the proliferation of HeLa cells and has no significant toxicity to the survival and proliferation of normal human keratinocytes (NK cells)^[1].
VHR-IN-7 (20 μM, 24 h) does not induce HeLa and CasKi cells apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HeLa and CasKi cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Did not induce HeLa and CasKi cells apoptosis.

Chemical Information

CAS. Nr. 1146616-17-2
Molecular Weight 612.14
Formel C₂₈H₂₂ClN₃O₅S₃
SMILES

ClC(C=CC=C1)=C1COC(C=C2)=CC=C2C3=NN(C4=CC=CC=C4)C=C3/C=C5C(N(C(S/5)=S)CCS(=O)(O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wu S, et al. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem. 2009 Nov 12;52(21):6716-23. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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