Platelet-activating Factor Receptor (PAFR)
The platelet-activating factor receptor (PAFR) is a G-protein-coupled receptor involved in both normal physiological and numerous pathophysiological processes. PAFR responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication that exhibits diverse physiological effects. Stimulation of the PAFR via binding of platelet-activating factor (PAF) elicits diverse and potent biological activities and plays a profound role in acute inflammation, allergic disorders, endotoxic shock, and anaphylaxis. PAF is a potent and versatile mediator of inflammation that is produced by numerous cell types and tissues, and particularly by leukocytes.
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Platelet-activating Factor Receptor (PAFR) Inhibitors
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Platelet-activating Factor Receptor (PAFR) Agonists
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Platelet-activating Factor Receptor (PAFR) Antagonists
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Platelet-activating Factor Receptor (PAFR) Activator
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Platelet-activating Factor Receptor (PAFR) Control
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Platelet-activating Factor Receptor (PAFR) Related Products (106)
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Antibodies (2)
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Pyrrolidino PAF C-16
0 ImagesCat. No.: HY-141612CAS No.: 91021-63-5Pyrrolidino PAF C-16 is a platelet activating factor ( PAF ) analogue that has hypohematic effects. -
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Rocepafant
0 ImagesCat. No.: HY-101654CAS No.: 132579-32-9Synonyms: BN 50730; LAU-8080Rocepafant (BN 50730) is a specific platelet activating factor (PAF) antagonist. Rocepafant can be used in rheumatoid arthritis and nervous system research. -
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Lexipafant
0 ImagesCat. No.: HY-105198CAS No.: 139133-26-9Synonyms: BB-882Lexipafant is a platelet-activating factor (PAF) antagonist that inhibits the inflammatory response and is used in the research of acute pancreatitis. -
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L-659,989
0 ImagesCat. No.: HY-121394CAS No.: 113787-28-3L-659,989 is an orally active, extremely potent, selective and competitive platelet activating factor (PAF) receptor antagonist. -
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WF-5239
0 ImagesCat. No.: HY-N19876CAS No.: 91224-36-1WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis. -
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(rel)-MK 287
0 ImagesCat. No.: HY-106899ACAS No.: 143445-03-8Synonyms: (rel)-L-680573(rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis. -
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E-6123
0 ImagesCat. No.: HY-10164CAS No.: 131614-02-3E-6123 is a platelet-activating factor (PAF) receptor antagonist. -
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F-0401
0 ImagesCat. No.: HY-177598CAS No.: 123852-99-3F-0401 is a calcium antagonist with platelet-activating factor receptor (PAFR) antagonistic action. F-0401 can be used for the research of neurological disease, such as stroke. -
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Bepafant
0 ImagesCat. No.: HY-121007CAS No.: 114776-28-2Synonyms: Web2170Bepafant (Web2170) is a platelet-activating factor (PAF) antagonist that protects against anaphylactic lethality in active and passive anaphylaxis models in mice and guinea pigs in a dose-dependent manner and attenuates bronchoconstriction and blood pressure changes in anaphylaxis. -
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Setipafant
0 ImagesCat. No.: HY-101675CAS No.: 132418-35-0Synonyms: BN-50727Setipafant is a platelet-activating factor (PAF) antagonist. -
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SDZ-62-434
0 ImagesCat. No.: HY-106833ACAS No.: 115621-95-9SDZ-62-434 is a platelet-activating factor (PAF) antagonist. SDZ-62-434 has antiproliferative activity in human solid and haematological malignancies. -
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Scandenolide
0 ImagesCat. No.: HY-118019CAS No.: 23758-16-9Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes. -
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Butenoyl-PAF
0 ImagesCat. No.: HY-126551CAS No.: 474944-25-7Butenoyl-PAF is a phospholipid analog of platelet activating factor (PAF-like) that is generated in oxidized low-density lipoprotein (DLDR). Butenoyl-PAF can activate cells that express human PAF receptors, such as neutrophils, monocytes, and platelets, and it stimulates an increase in intracellular calcium ion concentration. -
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Dersalazine
0 ImagesCat. No.: HY-167719CAS No.: 188913-58-8Synonyms: UR-12746 free baseDersalazine (UR-12746 free base) is an inhibitor of platelet-activating factor, exhibiting intestinal anti-inflammatory activity and potential efficacy in treating ulcerative colitis. -
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Ro 19-1400
0 ImagesCat. No.: HY-123399CAS No.: 122937-55-7Ro 19-1400 is a platelet-activating factor antagonist that directly inhibits immunoglobulin E-dependent mediator release. -
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1-Cinnamoylpyrrolidine
0 ImagesCat. No.: HY-N1620CAS No.: 52438-21-81-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA. 1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC50 of 37.3 μM. -
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L 651142
0 ImagesCat. No.: HY-124887CAS No.: 99046-40-9L 651142 is a weak platelet activating factor (PAF) receptor antagonist. L 651142 inhibits the binding of [3H]PAF to rabbit platelet, human platelet or human lung membranes with Kis of 0.839 μM, 1.82 μM, 3.64 μM, respectively. -
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Acopafant
0 ImagesCat. No.: HY-106038CAS No.: 125372-33-0Synonyms: Dacopafant; RP 55778 -
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ABT-299
0 ImagesCat. No.: HY-125309CAS No.: 161395-35-3ABT-299 is a prodrug of a platelet-activating factor (PAF) antagonist that exhibits significant inhibitory activity on PAF-induced β-platelet globulin release in vitro after in vivo administration in humans, an effect that may be partially attributed to the pyridine-N-oxide metabolite. -
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CV 3988
0 ImagesCat. No.: HY-106062CAS No.: 85703-73-7CV 3988 is a specific inhibitor of platelet-activating factor (PAF). -
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