Platelet-activating Factor Receptor (PAFR)
The platelet-activating factor receptor (PAFR) is a G-protein-coupled receptor involved in both normal physiological and numerous pathophysiological processes. PAFR responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell communication that exhibits diverse physiological effects. Stimulation of the PAFR via binding of platelet-activating factor (PAF) elicits diverse and potent biological activities and plays a profound role in acute inflammation, allergic disorders, endotoxic shock, and anaphylaxis. PAF is a potent and versatile mediator of inflammation that is produced by numerous cell types and tissues, and particularly by leukocytes.
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Platelet-activating Factor Receptor (PAFR) Inhibitors
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Platelet-activating Factor Receptor (PAFR) Agonists
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Platelet-activating Factor Receptor (PAFR) Antagonists
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Platelet-activating Factor Receptor (PAFR) Activator
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Platelet-activating Factor Receptor (PAFR) Control
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Platelet-activating Factor Receptor (PAFR) Related Products (108)
Related Products (108)
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Antibodies (2)
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CV-6209 (Standard)
0 ImagesCat. No.: HY-109897RCAS No.: 100488-87-7CV-6209 (Standard) is the analytical standard of CV-6209 (HY-109897). This product is intended for research and analytical applications. CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats.
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ONO-6240
0 ImagesCat. No.: HY-113635CAS No.: 99659-62-8ONO-6240 is a platelet-activating factor antagonist. ONO-6240 prevents EOS infiltration into airway. ONO-6240 can be used in the study of asthmatic.
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SCH-44643
0 ImagesCat. No.: HY-123397CAS No.: 133330-43-5SCH-44643 is an orally active platelet activating factor (PAF) and histamine antagonist.
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Aggreceride C
0 ImagesCat. No.: HY-N14934CAS No.: 104700-86-9Aggreceride C is a platelet aggregation inhibitor. Aggreceride C shows an inhibitory activity against aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590) and PAF (platelet activating factor), but was less active against aggregation induced by collagen.
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(2S,5S)-CMI-392
0 ImagesCat. No.: HY-19205BCAS No.: 205654-37-1(2S,5S)-CMI-392 is the absolute configuration of CMI-392 (HY-19205A). CMI-392 is an orally active dual 5-lipoxygenase inhibitor and platelet-activating factor receptor (PAFR) antagonist, with an IC50 of 10 nM for human PAF receptor and an IC50 of 100 nM for rat 5-lipoxygenase. CMI-392 blocks PAF receptor binding, inhibits leukotriene synthesis, attenuates PAF-induced hemoconcentration, and suppresses arachidonic acid- and TPA-induced ear swelling in mice. CMI-392 reduces inflammatory cell infiltration, decreases MPO levels, alleviates ocular inflammation, and improves dextran sulfate sodium-induced colitis. CMI-392 can be used in the research of inflammatory and immune-related diseases such as colitis and atopic dermatitis.
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48740 RP
0 ImagesCat. No.: HY-100153CAS No.: 93363-11-2Synonyms: (Rac)-RP-5577848740 RP ((Rac)-RP-55778) is a platelet-activating factor (PAF) antagonist.
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CMI-392
0 ImagesCat. No.: HY-19205ACAS No.: 193739-23-0Synonyms: LDP-392CMI-392 (LDP-392) is an orally active dual 5-lipoxygenase inhibitor and platelet-activating factor receptor (PAFR) antagonist, with an IC50 of 10 nM for human PAF receptor and an IC50 of 100 nM for rat 5-lipoxygenase. CMI-392 blocks PAF receptor binding, inhibits leukotriene synthesis, attenuates PAF-induced hemoconcentration, and suppresses arachidonic acid- and TPA-induced ear swelling in mice. CMI-392 reduces inflammatory cell infiltration, decreases MPO levels, alleviates ocular inflammation, and improves dextran sulfate sodium-induced colitis. CMI-392 can be used in the research of inflammatory and immune-related diseases such as colitis and atopic dermatitis.
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PAF-AN-1
0 ImagesCat. No.: HY-U00040CAS No.: 115621-84-6PAF-AN-1 is a platelet activating factor receptor (PAF) antagonist.
