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CV-6209 

Cat. No.: HY-109897
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CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats.

For research use only. We do not sell to patients.

CV-6209 Chemical Structure

CV-6209 Chemical Structure

CAS No. : 100488-87-7

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Description

CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats[1].

IC50 & Target

platelet activating factor (PAF)[1]

In Vitro

CV-6209 inhibits [3H]serotonin release from rabbit platelets stimulated with PAF (30 nM)[1].
CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen[1].
CV-6209 (0.2-2 μM; pretreated for 30 min) inhibits PAF-induced MC degranulation in both LAD2 and hLMCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CV-6209 (i.v.) inhibits PAF (0.3 μg/kg; i.v.)-induced hypotension in rats (ED50=0.009 mg/kg) with no effect on the hypotension induced by arachidonic acid, histamine, bradykinin and isoproterenol[1].
CV-6209 (66 μg; i.v.) reduces asparaginase-induced hypersensitivity compared with nonpretreated, sensitized mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

642.31

Formula

C₃₄H₆₀ClN₃O₆

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CV-6209
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