2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. BAY 1135626

BAY 1135626 is used to synthesize BAY 1129980, and use to anti-tumor research. BAY 1129980 is a Auristatin-based anti-C4.4A (LYPD3) antibody–agent conjugate (ADC), is used to non–small cell lung cancer (NSCLC) research.

For research use only. We do not sell to patients.

BAY 1135626 Chemical Structure

BAY 1135626 Chemical Structure

CAS No. : 1404071-37-9

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BAY 1135626 Related Antibodies

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Description

BAY 1135626 is used to synthesize BAY 1129980, and use to anti-tumor research. BAY 1129980 is a Auristatin-based anti-C4.4A (LYPD3) antibody–agent conjugate (ADC), is used to non–small cell lung cancer (NSCLC) research[1].

In Vitro

C4.4A (LYPD3) is a protein expressed in non-small cell lung cancer (NSCLC), with scarcely expressing in normal tissues[1].
BAY 1135626 can be synthesized into BAY 1129980 (C4.4A-ADC), shows a strong anti-proliferative effect on C4.4A expressing cell lines[1].
BAY 1129980 (0.001-100 nM; 72 h) inhibits the proliferation of A549 lung cancer cell lines transfected with C4.4A[1].
BAY 1129980 (0.001-100 nM; 72 h) exhibits high and selective efficacy on hC4.4A:A549 cells in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY 1135626 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: hC4.4A:A549 lung cancer cells
Concentration: 0.001-100 nM
Incubation Time: 72 hours
Result: High potency at subnanomolar range with an IC50 value of 0.05 nM.
Resulted remarkable selectivity on hC4.4A:A549 with over 1,000-fold compared with mock:A549 cells.

Cell Viability Assay[1]

Cell Line: NCI-H292, FaDu, NCI-H322, SCaBER, SCC-4
Concentration: 0.001-100 nM
Incubation Time: 72 hours
Result: Inhibited cancer cell growth in a dose-dependent manner.
In Vivo

BAY 1129980 (1.9-7.5 mg/kg; i.v.; 20 d) inhibits tumor growth in vivo in mouse[1].
BAY 1129980 with a repeated dosing (15 mg/kg; i.v.; 21 d for 1st cycle and 57 d for 2nd cycle) is well tolerated without changing the sensitivity to the treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C4.4A-positive NCI-H292 NSCLC xenograft mouse model[1]
Dosage: 1.9, 3.75, 7.5 mg/kg
Administration: Intravenous injection; 20 days
Result: Halted tumor growth on day 20 dose dependently, as the monotherapy treatment, with a minimum effective dose (MED) of 1.9 mg/kg.
Animal Model: C4.4A-positive NCI-H292 NSCLC xenograft mouse model[1]
Dosage: 15 mg/kg
Administration: Intravenous injection; 21 days for the first cycle teament, 57 days for the second cycle treatment
Result: Reduced tumor volume with a marked delay of tumor growth.
Demonstrated well tolerance, still left regrown tumors sensitive to treatment.
Molecular Weight

1063.33

Formula

C55H86N10O11
CAS No.
SMILES

CO[C@@H]([C@@]1([H])N(CCC1)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)CCCC(NNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)=O)=O)[C@@H](C)C(N[C@H](C(N)=O)CC3=CNC4=CC=CC=C34)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BAY 1135626 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 11356261404071-37-9BAY1135626BAY-1135626Drug-Linker Conjugates for ADCnon–small cell lung cancerNSCLCBAY 1129980anti-tumorC4.4A-ADCantibody–drug conjugateAuristatinLYPD3Inhibitorinhibitorinhibit

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