WD repeat-containing protein 20
Definition:
Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme.
References:
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[1]. Younghoon Kee, et al. WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem. 2010 Apr 9;285(15):11252-7. [Content Brief]
[2]. Heng Li, et al. Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20. Mol Cell. 2016 Jul 21;63(2):249-260. [Content Brief]
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