2. Epigenetics Apoptosis
  3. Histone Demethylase Apoptosis
  4. Bomedemstat hydrochloride

Bomedemstat hydrochloride  (Synonyms: IMG-7289 hydrochloride)

Cat. No.: HY-109169B Purity: 99.55%
COA Handling Instructions

Bomedemstat (IMG-7289) hydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat hydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat hydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis.

For research use only. We do not sell to patients.

Bomedemstat hydrochloride Chemical Structure

Bomedemstat hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 360 In-stock
10 mg USD 580 In-stock
25 mg USD 1150 In-stock
50 mg USD 1850 In-stock
100 mg USD 2980 In-stock
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Based on 1 publication(s) in Google Scholar

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Bomedemstat hydrochloride Related Antibodies

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Description

Bomedemstat (IMG-7289) hydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat hydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat hydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis[1][2].

In Vitro

Bomedemstat selectively inhibits proliferation and induces apoptosis of Jak2V617F cells by concomitantly increasing expression and methylation of p53[1].
Bomedemstat (50 nM-1 μM; 96 h) enhances survival, induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner, and leads to cell cycle arrest[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bomedemstat hydrochloride Related Antibodies

Apoptosis Analysis[1]

Cell Line: SET-2 cells
Concentration: 50 nM, 100 nM, and 1 μM
Incubation Time: 96 hours
Result: Decreased levels of the antiapoptotic protein BCL-XL and increased levels of the pro-apoptotic protein PUMA.
In Vivo

Bomedemstat treatment (oral gavage; 45 mg/kg; once daily; 56 d) normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mx-Jak2V617F mice[1]
Dosage: 45 mg/kg
Administration: Oral gavage; 45 mg/kg; once daily; 56 days
Result: Reduced splenomegaly significantly with a few treated mice normalizing their spleen weight, the 56-day course led to partial restoration of lymph follicles and spleen architecture by histological examination.
Clinical Trial
Molecular Weight

556.07

Appearance

Oil

Formula

C28H35ClFN7O2
SMILES

O=C(N1CCN(CC1)C)[C@@H](NC(C2=CC=C(N3C=CN=N3)C=C2)=O)CCCN[C@H]4[C@@](C5=CC=C(C=C5)F)([H])C4.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (179.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7983 mL 8.9917 mL 17.9833 mL
5 mM 0.3597 mL 1.7983 mL 3.5967 mL
10 mM 0.1798 mL 0.8992 mL 1.7983 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Bomedemstat hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

BomedemstatIMG-7289IMG7289IMG 7289Histone DemethylaseApoptosisoral activitylysine-specific demethylase 1anti-cancer activityanti-proliferationinduce apoptosisSET-2Inhibitorinhibitorinhibit

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