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Cat. No.: HY-107752

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2-(Phenylethynyl)-ATP

2-(Phenylethynyl)-ATP is an analog of ATP (HY-B2176). 2-(Phenylethynyl)-ATP can generate an AdoMet (HY-B0617) analog (2-(phenylethynyl)-AdoONB). 2-(phenylethynyl)-AdoONB derived from 2-(Phenylethynyl)-ATP shows no activity against methyltransferases NovO, RnCOMT-var and GlaTgs2-var.

For research use only. We do not sell to patients.

CAS No.: 851265-78-6
Formula: C₁₈H₂₀N₅O₁₃P₃
Molecular Weight:607.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-(Phenylethynyl)-ATP Chemical Structure

CAS No.: 851265-78-6

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Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

2-(phenylethynyl)-ATP (Compound o1) (2.5 mM; 6 h) mediates mediocr conversion of ortho-nitrobenzyl-DL-homocysteine by PC-MjMAT, with negligible conversion of propargyl-L-selenohomocysteine, and the resulting 2-(phenylethynyl)-AdoONB product forms strong van der Waals interactions with PC-MjMAT that suggest product inhibition^[1].
2-(phenylethynyl)-ATP (2.5 mM; 6 h) supports minimal NovO-mediated THPC modification via ortho-nitrobenzyl group transfer and negligible propargyl group transfer in PC-MjMAT/MTase cascade reactions^[1].
2-(phenylethynyl)-ATP (2.5 mM; 6 h) does not support measurable RnCOMT-var-mediated DHBAL modification via either ortho-nitrobenzyl or propargyl group transfer in PC-MjMAT/MTase cascade reactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 851265-78-6
Molecular Weight 607.30
Formula C₁₈H₂₀N₅O₁₃P₃
SMILES

O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O[C@H]1N2C3=NC(C#CC4=CC=CC=C4)=NC(N)=C3N=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Erguven M, et al. Enzymatic Generation of Double-Modified AdoMet Analogues and Their Application in Cascade Reactions with Different Methyltransferases. Chembiochem : a European journal of chemical biology. 2022 Dec 16;23(24):e202200511. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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