Buforin II
Based on 1 Customer Validation
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria.
For research use only. We do not sell to patients.
- Purity: 95.35%
- CAS No.: 172998-24-2
- Formula: C106H184N40O26
- Molecular Weight:2434.85
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Buforin II inhibits A. baumanniiATCC 19606 and multiresistant strains with the similar MIC values of 8 mg/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats weighing 200 to 300 g with A. baumannii ATCC 19606[1]
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Dosage:1 mg/kg
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Administration:Intravenously a single dose
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Result:Reduced mortality by 40% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.
Reduced TNF, IL-6 and endotoxin plasma levels by 33%, 25% and 32%, respectively.
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Animal Model:Male Wistar rats weighing 200 to 300 g with the multiresistant strain[1]
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Dosage:1 mg/kg
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Administration:Intravenously a single dose
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Result:Reduced mortality by 46.6% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.
Reduced TNF, IL-6 and endotoxin plasma levels by 46%, 20% and 28%, respectively.
Chemical Information
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CAS No. 172998-24-2
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Appearance Solid
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Molecular Weight 2434.85
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Formula C106H184N40O26
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Color White to off-white
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Sequence Shortening
TRSSRAGLQFPVGRVHRLLRK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
H2O : 100 mg/mL (41.07 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.4107 mL | 2.0535 mL | 4.1070 mL | 10.2676 mL |
| 5 mM | 0.0821 mL | 0.4107 mL | 0.8214 mL | 2.0535 mL | |
| 10 mM | 0.0411 mL | 0.2054 mL | 0.4107 mL | 1.0268 mL | |
| 15 mM | 0.0274 mL | 0.1369 mL | 0.2738 mL | 0.6845 mL | |
| 20 mM | 0.0205 mL | 0.1027 mL | 0.2054 mL | 0.5134 mL | |
| 25 mM | 0.0164 mL | 0.0821 mL | 0.1643 mL | 0.4107 mL | |
| 30 mM | 0.0137 mL | 0.0685 mL | 0.1369 mL | 0.3423 mL | |
| 40 mM | 0.0103 mL | 0.0513 mL | 0.1027 mL | 0.2567 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Buforin II Related Classifications
HY-P1630 Related Classifications
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