STAG2 - stromal antigen 2 Gene

Also Known as SA2; MKMS; SA-2; HPE13; SCC3B; NEDXCF; bA517O1.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10735

About STAG2

Cytogenetic location: Xq25 Genomic coordinates (GRCh38): X:123,960,560-124,102,656 (from NCBI)

This gene has 29 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 138 phenotypes. Ubiquitous expression in thyroid (RPKM 24.4), bone marrow (RPKM 22.3) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human Cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

STAG2 Products (17)

mRNA	Protein	Name
NM_001042749.2	NP_001036214.1	cohesin subunit SA-2 isoform a
NM_001042750.2	NP_001036215.1	cohesin subunit SA-2 isoform a
NM_001042751.2	NP_001036216.1	cohesin subunit SA-2 isoform b
NM_001282418.2	NP_001269347.1	cohesin subunit SA-2 isoform b
NM_001375366.1	NP_001362295.1	cohesin subunit SA-2 isoform a
NM_001375367.1	NP_001362296.1	cohesin subunit SA-2 isoform a
NM_001375368.1	NP_001362297.1	cohesin subunit SA-2 isoform a
NM_001375369.1	NP_001362298.1	cohesin subunit SA-2 isoform a
NM_001375370.1	NP_001362299.1	cohesin subunit SA-2 isoform a
NM_001375371.1	NP_001362300.1	cohesin subunit SA-2 isoform a
NM_001375372.1	NP_001362301.1	cohesin subunit SA-2 isoform a
NM_001375373.1	NP_001362302.1	cohesin subunit SA-2 isoform b
NM_001375374.1	NP_001362303.1	cohesin subunit SA-2 isoform b
NM_001375375.1	NP_001362304.1	cohesin subunit SA-2 isoform b
NM_001375376.1	NP_001362305.1	cohesin subunit SA-2 isoform b
NM_001375377.1	NP_001362306.1	cohesin subunit SA-2 isoform b
NM_006603.5	NP_006594.3	cohesin subunit SA-2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15737063	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	11590136	GOA
involved in sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	15917200	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	16682347	GOA
part of cohesin complex	IDA IDA: Inferred from direct assay	11590136	GOA
part of cohesin complex	IMP IMP: Inferred from mutant phenotype	29263825	GOA
part of mitotic cohesin complex	IPI IPI: Inferred from physical interaction	23242214	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	11590136	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	11590136	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAG2 Protein Structure

STAG

0
200
400
600
800
1000
1200
1268 a.a.

Protein Preferred Names	Protein Names
cohesin subunit SA-2	SCC3 homolog 2

STAG2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STAG2	Q8N3U4	WAPL	Homo sapiens	Q7Z5K2	Anti Tag CoIP	25173175
Intra	STAG2	Q8N3U4	WAPL	Homo sapiens	Q7Z5K2	Pull Down	29263825
Intra	STAG2	Q8N3U4	WAPL	Homo sapiens	Q7Z5K2	Anti Bait CoIP	29867216
Intra	STAG2	Q8N3U4	WAPL	Homo sapiens	Q7Z5K2	Anti Tag CoIP	35271311
Intra	STAG2	Q8N3U4	WAPL	Homo sapiens	Q7Z5K2	Anti Tag CoIP	29263825
Intra	STAG2	Q8N3U4	WAPL	Homo sapiens	Q7Z5K2	Anti Bait CoIP	17113138
Intra	STAG2	Q8N3U4	STAG1	Homo sapiens	Q8WVM7	TAP	24981860
Intra	STAG2	Q8N3U4	STAG1	Homo sapiens	Q8WVM7	Anti Bait CoIP	29867216
Intra	STAG2	Q8N3U4	STAG1	Homo sapiens	Q8WVM7	Anti Bait CoIP	17962804
Intra	STAG2	Q8N3U4	PDS5A	Homo sapiens	Q29RF7	Anti Bait CoIP	29867216
Intra	STAG2	Q8N3U4	PDS5A	Homo sapiens	Q29RF7	Anti Tag CoIP	29263825
Intra	STAG2	Q8N3U4	PDS5A	Homo sapiens	Q29RF7	Anti Bait CoIP	17113138
Intra	STAG2	Q8N3U4	PDS5A	Homo sapiens	Q29RF7	Anti Tag CoIP	35271311
Intra	STAG2	Q8N3U4	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	15855230
Intra	STAG2	Q8N3U4	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	29867216
Intra	STAG2	Q8N3U4	PDS5B	Homo sapiens	Q9NTI5	Anti Bait CoIP	17113138
Intra	STAG2	Q8N3U4	SSU72	Homo sapiens	Q9NP77	Pull Down	20818333
Intra	STAG2	Q8N3U4	SMC1A	Homo sapiens	Q14683	Anti Bait CoIP	19629043
Intra	STAG2	Q8N3U4	SMC1A	Homo sapiens	Q14683	Anti Bait CoIP	17113138
Intra	STAG2	Q8N3U4	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	29263825
Intra	STAG2	Q8N3U4	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	35271311
Intra	STAG2	Q8N3U4	SMC1A	Homo sapiens	Q14683	TAP	24981860
Intra	STAG2	Q8N3U4	SMC1A	Homo sapiens	Q14683	Anti Bait CoIP	29867216
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	22885700
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	19629043
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	17962804
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	17113138
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	Anti Tag CoIP	35271311
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	29867216
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	TAP	24981860
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	15855230
Intra	STAG2	Q8N3U4	SMC3	Homo sapiens	Q9UQE7	Anti Tag CoIP	29263825
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Anti Bait CoIP	19629043
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17962804
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17113138
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	X-Ray Diffraction	25173175
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Anti Tag CoIP	35271311
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Anti Bait CoIP	22885700
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Anti Bait CoIP	29867216
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	TAP	24981860
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Pull Down	29263825
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	GMS	25173175
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Anti Tag CoIP	29263825
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Pull Down	25173175
Intra	STAG2	Q8N3U4	RAD21	Homo sapiens	O60216	Anti Tag CoIP	25173175
Intra	STAG2	Q8N3U4	SGO1	Homo sapiens	Q5FBB7	Pull Down	29263825

Cross: Cross-species interaction Intra: Intraspecies interaction

STAG2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81402	SA2 Antibody (YA1147)	IHC-P	Human
HY-P81402A	SA2 Antibody (YA1147)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Mullegama-Klein-Martinez Syndrome	MKMS Nedxcf Neurodevelopmental Disorder, X-Linked, With Craniofacial Abnormalities X-Linked Neurodevelopmental Disorder With Craniofacial Abnormalities
Holoprosencephaly 13, X-Linked	HPE13
Alobar Holoprosencephaly
Semilobar Holoprosencephaly
Chromosome Xq25 Duplication Syndrome	Xq25 Microduplication Syndrome Xq25 Duplication Syndrome Dup Xq25 Microtriplication
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Laryngotracheitis
Acute Myeloid Leukemia With Bcr-Abl1	Acute Myeleoid Leukemia With Bcr-Abl1
Septooptic Dysplasia	Septo-Optic Dysplasia De Morsier Syndrome Growth Hormone Deficiency With Pituitary Anomalies SOD Pituitary Hormone Deficiency, Combined, 5 Septo-Optic Dysplasia Spectrum Septo-Optic Dysplasia With Growth Hormone Deficiency Pituitary Hormone Deficiency, Combined 5 Hypopituitarism And Septooptic 'Dysplasia' GHDPA CPHD5 Dysplasia, Septo-Optic Kallmann Syndrome
Breast Juvenile Papillomatosis	Juvenile Papillomatosis Of The Breast
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Holoprosencephaly 7	HPE7 Holoprosencephaly-7 Holoprosencephaly, Type 7
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Roberts-Sc Phocomelia Syndrome	Roberts Syndrome Sc Phocomelia Syndrome RBS Long Bone Deficiencies Associated With Cleft Lip-Palate Sc Pseudothalidomide Syndrome Appelt-Gerken-Lenz Syndrome Pseudothalidomide Syndrome Tetraphocomelia-Cleft Palate Syndrome Hypomelia Hypotrichosis Facial Hemangioma Syndrome Roberts Syndrome/Sc Phocomelia Roberts Tetraphocomelia Syndrome Sc Syndrome Sc Phocomelia Sc Disease Sc Hemoglobin Sc Disease
Immunodeficiency 21	Monocytopenia And Mycobacterial Infection Syndrome Monomac Gata2 Deficiency Monocytopenia With Susceptibility To Infections Dcml IMD21 Dendritic Cell, Monocyte, B Lymphocyte, And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral, And Fungal Infections Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral And Fungal Infections Dendritic Cell, Monocyte, B And Nk Lymphoid Deficiency Monocyte-B-Natural Killer-Dendritic Cell Deficiency Syndrome Monocytopenia With Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Mycobacterial, Viral, And Fungal Infections Monocyte - B - Natural Killer - Dendritic Cell Deficiency Combined Immunodeficiency With Susceptibility To Mycobacterial Viral And Fungal Infections Dendritic Cell Monocyte Lymphocyte B And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial Fungal And Papillomavirus Infections And Myelodysplasia
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13867	STAG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STAG2	VGNC	VGNC:65744
Rattus norvegicus	STAG2	RGD	RGD:1562042
Mus musculus	STAG2	MGD	MGI:1098583
Bos taurus	STAG2	VGNC	VGNC:35354
Canis familiaris	STAG2	VGNC	VGNC:46874
Others	STAG2	NCBI