SA2 Antibody (YA1147)(PBS only)

Cat. No.: HY-P81402A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

SA2 Antibody (YA1147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SA2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

SA2 Antibody (YA1147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SA2.

Host

Rabbit

Molecular Weight

Predicted band size: 141 kDa;

Observed band size: 141 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q8N3U4

Gene ID

10735 [NCBI]

Immunogen

Recombinant protein of human SA2

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis

Subcellular Localization：Nucleus; Chromosome; Chromosome, centromere

Isoforms & Post-Translational Modification：Q8N3U4 has 2 isomers: Q8N3U4-1: 141326 Da (predicted); Q8N3U4-2: 145751 Da (predicted).
Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity)

Subunit：Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3

Research Field

Cell Biology

Synonyms

SA 2; SA-2; SA2; SCC3 homolog 2; SCC3B; stag2; Stromal antigen 2

Documentation

User Guide for Antibodies (1077 KB)