HEPES-d18
Based on 1 publication(s) in Google Scholar
HEPES-d18 is the deuterium labeled HEPES. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 203805-87-2
- Formula: C8D18N2O4S
- Molecular Weight:256.42
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) HEPES-d18
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 203805-87-2
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Unlabeled Cas 7365-45-9
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Appearance Solid
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Molecular Weight 256.42
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Formula C8D18N2O4S
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Color White to off-white
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SMILES
O=S(C([2H])([2H])C([2H])([2H])N1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])O[2H])(O[2H])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Development of pH-adjusted NMR methodology for quantitation of caffeoylquinic acid derivatives and evaluation of their antimalignant pleural mesothelioma potential. [Abstract]2025 Jul 15:259:116776. PMID: 40024029
Solvent & Solubility
H2O : 100 mg/mL (389.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [Content Brief]
[3]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 201066(Pt 4):482-492. [Content Brief]
[4]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 201814(3):437-449. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.8999 mL | 19.4993 mL | 38.9985 mL | 97.4963 mL |
| 5 mM | 0.7800 mL | 3.8999 mL | 7.7997 mL | 19.4993 mL | |
| 10 mM | 0.3900 mL | 1.9499 mL | 3.8999 mL | 9.7496 mL | |
| 15 mM | 0.2600 mL | 1.3000 mL | 2.5999 mL | 6.4998 mL | |
| 20 mM | 0.1950 mL | 0.9750 mL | 1.9499 mL | 4.8748 mL | |
| 25 mM | 0.1560 mL | 0.7800 mL | 1.5599 mL | 3.8999 mL | |
| 30 mM | 0.1300 mL | 0.6500 mL | 1.3000 mL | 3.2499 mL | |
| 40 mM | 0.0975 mL | 0.4875 mL | 0.9750 mL | 2.4374 mL | |
| 50 mM | 0.0780 mL | 0.3900 mL | 0.7800 mL | 1.9499 mL | |
| 60 mM | 0.0650 mL | 0.3250 mL | 0.6500 mL | 1.6249 mL | |
| 80 mM | 0.0487 mL | 0.2437 mL | 0.4875 mL | 1.2187 mL | |
| 100 mM | 0.0390 mL | 0.1950 mL | 0.3900 mL | 0.9750 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
HEPES-d18 Related Classifications
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