203805-87-2
203805-87-2
Chemical Structure
HEPES-d18
- CAS No.: 203805-87-2
- Formula:C8D18N2O4S
- Molecular Weight:256.42
IUPAC Name: 2-(4-(2-(hydroxy-d)ethyl-1,1,2,2-d4)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)ethane-1-sulfonic-1,1,2,2-d4 acid-d
InChIKey: JKMHFZQWWAIEOD-MMODJCGESA-N
SMILES: O=S(C([2H])([2H])C([2H])([2H])N1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])O[2H])(O[2H])=O
Biological Activity: HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].
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HEPES-d18 | 99.89% | HEPES-d18 is the deuterium labeled HEPES. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis. | ||||||||||||||||||||
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HEPES | 99.94% | HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [Content Brief]
- [3]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 201066(Pt 4):482-492. [Content Brief]
- [4]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 201814(3):437-449. [Content Brief]
