3-Chloro-L-tyrosine
Based on 1 publication(s) in Google Scholar
3-Chloro-L-tyrosine is a specific biomarker in myeloperoxidase-catalyzed oxidation. 3-Chloro-L-tyrosine can be used as a molecular marker for oxidative stress and inflammation to determine whether myeloperoxidase-mediated tyrosine chlorination occurs. 3-Chloro-L-tyrosine is therefore used in the diagnosis of chlorine poisoning in forensic toxicology and in the auxiliary diagnosis of inflammation such as colorectal cancer.
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- Pureté: 98.13%
- CAS No.: 7423-93-0
- Formule: C9H10ClNO3
- Masse moléculaire:215.64
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Solvant et solubilité
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Publications Citing Use of MedChemExpress (MCE) 3-Chloro-L-tyrosine
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Activité biologique
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Human Endogenous Metabolite |
The detection limit of 3-Chloro-L-tyrosine purified by protein precipitation and cation exchange solid phase extraction is 5 ng/mL, and the concentration in the left heart blood of chlorine poisoning autopsy reaches 59.7 ng/mL [1].
The detection limit of 3-Chloro-L-tyrosine (0.1-3.0 ng/mL; during the analysis) after acetone liquid-liquid extraction is 0.03 ng/mL, and the concentration in the plasma of colorectal cancer patients (1.20 ng/mL) is significantly higher than that of healthy controls (0.52 ng/mL)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7423-93-0
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Appearance Solid
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Masse moléculaire 215.64
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Formule C9H10ClNO3
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Color White to off-white
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SMILES
O=C(O)[C@@H](N)CC1=CC=C(O)C(Cl)=C1
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Synonyms
3-Chlorotyrosine
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvant et solubilité
H2O : 5 mg/mL (23.19 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 6.25 mg/mL (28.98 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Pureté et documentation
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Fiche technique (273 KB)
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SDS (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Nishio T, et al. Determination of 3-chloro-l-tyrosine as a novel indicator of chlorine poisoning utilizing gas chromatography-mass spectrometric analysis. Leg Med (Tokyo). 2020 Nov;47:101782. [Content Brief]
[2]. Fleszar MG, et al. Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period. Molecules. 2020 Nov 5;25(21):5158. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.6374 mL | 23.1868 mL | 46.3736 mL | 115.9340 mL |
| 5 mM | 0.9275 mL | 4.6374 mL | 9.2747 mL | 23.1868 mL | |
| 10 mM | 0.4637 mL | 2.3187 mL | 4.6374 mL | 11.5934 mL | |
| 15 mM | 0.3092 mL | 1.5458 mL | 3.0916 mL | 7.7289 mL | |
| 20 mM | 0.2319 mL | 1.1593 mL | 2.3187 mL | 5.7967 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
3-Chloro-L-tyrosine Related Classifications
HY-W041171 Related Classifications
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