ActRIIB-IN-1
ActRIIB-IN-1, 7-azaindole compound is an orally active activin type II receptor B (ActRIIB) inhibitor with an IC50 of 1.8 nM. ActRIIB-IN-1 can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite. ActRIIB-IN-1 can be used for the research of cancer cachexia.
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- CAS No.: 3039974-31-4
- Formule: C21H22N6
- Masse moléculaire:358.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
ActRIIB-IN-1 (Compound 2) (1.25-5 μM; 48 h) alleviates C2C12 mature myotube atrophy induced by C26 cell culture medium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12 mature myotube
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Concentration:1.25, 2.5, 5 μM
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Incubation Time:48 h
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Result:Showed atrophy reversal rate of 69.2, 97.61 and 130.63%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with C26 tumor cells[1]
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Dosage:5 mg/kg
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Administration:i.g.; qd; 24 days
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Result:Alleviated weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite.
Did not inhibit tumor growth.
Chemical Information
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CAS No. 3039974-31-4
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Masse moléculaire 358.45
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Formule C21H22N6
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SMILES
N=1C=C(C=C2C1NC=C2C3=NNC=C3)C=4C=CC(=CC4)N5CCN(C)CC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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