ALK-IN-31
ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor (IC50: 1135 nM). ALK-IN-31 exhibits excellent antiproliferative activity against lung cancer H2228 cells with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation in the G0/G1 phase by affecting mitochondrial function. ALK-IN-31 exerts its anti-tumor effect by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. ALK-IN-31 can be used in the study of non-small cell lung cancer (NSCLC).
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- CAS No.: 3043840-25-8
- Formule: C30H33N5O2S
- Masse moléculaire:527.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Chemical Information
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CAS No. 3043840-25-8
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Masse moléculaire 527.68
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Formule C30H33N5O2S
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SMILES
O=C(C1CCCCC1)NC2=CC=CC=C2NC3=C(CSCC4)C4=NC(NC(C=C5CCC6)=CC=C5C6=O)=N3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALK-IN-31 Related Classifications
HY-173493 Related Classifications
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