Aminocandin
Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp..
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 227472-48-2
- Formule: C56H79N9O14
- Masse moléculaire:1102.28
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Fungal[1]
Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L[2].
Aminocandin shows half-life of 48-58 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Immunosuppressed male CD1 mice, Aspergillus fumigatus infection model[1]
-
Dosage:10, 5, 1 and 0.25 mg/kg (IV) or 1 mg/kg (IP)
-
Administration:IV or IP, once daily for 11 days
-
Result:Increased the survival rate, 5 mg/kg i.v. yielded 100% survival following infection with AF91.
Chemical Information
-
CAS No. 227472-48-2
-
Masse moléculaire 1102.28
-
Formule C56H79N9O14
-
Synonyms
HMR 3270; IP960; NXL201
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Warn PA, et al. Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus. Int J Antimicrob Agents. 2010 Feb;35(2):146-51. [Content Brief]
[2]. Ghannoum MA, et al. Efficacy of aminocandin in the treatment of immunocompetent mice with haematogenously disseminated fluconazole-resistant candidiasis. J Antimicrob Chemother. 2007 Mar;59(3):556-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aminocandin Related Classifications
HY-P0068 Related Classifications
Powered by Bioz