DLK-IN-2
DLK-IN-2 is a selective inhibitor of DLK and neuroprotective agent. DLK-IN-2 shows no significant inhibition against CYPs 3A4, 2D6 and 2C9. DLK-IN-2 inhibits acute axonal palmitoylation of DLK, blocks DLK-dependent pro-degenerative axon-to-soma retrograde signaling and suppresses c-Jun phosphorylation. DLK-IN-2 can be used for the mechanistic study of neurodegenerative diseases.
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- CAS No.: 883012-32-6
- Formule: C23H25ClN2O3S
- Masse moléculaire:444.97
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Activité biologique
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MAP3K12/DLK |
DLK-IN-2 (compound 13) (10 μM; 1 h pre-incubation, 2.5 h post-deprivation) significantly inhibits trophic factor deprivation-induced c-Jun phosphorylation in primary embryonic day 16 rat DRG neurons[1].
DLK-IN-2 (10 μM; 1 h pre-incubation, 45 h post-deprivation) significantly protects primary embryonic day 16 rat DRG neurons from trophic factor deprivation-induced neurodegeneration[1].
DLK-IN-2 (10 μM; 4 h post-injury) transiently reduces acute axotomy-induced Wallerian degeneration in primary embryonic day 16 rat DRG neuron spot cultures, but does not protect axons at 6 h post-injury[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Embryonic rat DRG neurons
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Concentration:10 μM
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Incubation Time:2.5 h (p-c-Jun); 4 h (NMNAT2, STMN2)
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Result:Significantly reduced TD-induced c-Jun phosphorylation; did not stabilize NMNAT2 or STMN2.
Chemical Information
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CAS No. 883012-32-6
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Masse moléculaire 444.97
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Formule C23H25ClN2O3S
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SMILES
O=S(C1=CC=C(NC(C2=CC=C(Cl)C=C2)=O)C=C1)(NC34CC5CC(C4)CC(C5)C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DLK-IN-2 Related Classifications
HY-181662 Related Classifications
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