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PPIH - peptidylprolyl isomerase H Gene

Also Known as CYPH; CYP-20; USA-CYP; SnuCyp-20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10465

About PPIH

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,658,423-42,681,654 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and 22 paralogues. Ubiquitous expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]

PPIH Products (2)

mRNA	Protein	Name
NM_001330510.2	NP_001317439.1	peptidyl-prolyl cis-trans isomerase H isoform 2
NM_006347.4	NP_006338.1	peptidyl-prolyl cis-trans isomerase H isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	9570313	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9570313	GOA
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	9570313	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	19932913	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of U4/U6 snRNP	IDA IDA: Inferred from direct assay	9570313	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	9570313	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9570313	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	9570313	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIH Protein Structure

Pro_isomerase

0
100
177 a.a.

Protein Preferred Names	Protein Names
peptidyl-prolyl cis-trans isomerase H	PPIase h

PPIH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PPIH	O43447	DOK3	Homo sapiens	Q7L591-3	Validated Y2H	32296183
Intra	PPIH	O43447	DOK3	Homo sapiens	Q7L591-3	Y2H Array	32296183
Intra	PPIH	O43447	DOK3	Homo sapiens	Q7L591-3	Y2H Prey Pooling	32296183
Intra	PPIH	O43447	N4BP2L2	Homo sapiens	Q92802	Y2H Prey Pooling	25416956
Intra	PPIH	O43447	N4BP2L2	Homo sapiens	Q92802	Validated Y2H	25416956
Intra	PPIH	O43447	N4BP2L2	Homo sapiens	Q92802	Y2H Prey Pooling	32296183
Intra	PPIH	O43447	N4BP2L2	Homo sapiens	Q92802	Validated Y2H	32296183
Intra	PPIH	O43447	N4BP2L2	Homo sapiens	Q92802	Y2H Array	32296183
Cross	PPIH	O43447	P0C6X7-PRO_0000037309	Human SARS coronavirus	P0C6X7-PRO_0000037309	Lumier	22046132
Cross	PPIH	O43447	P0C6X7-PRO_0000037309	Human SARS coronavirus	P0C6X7-PRO_0000037309	Y2H Pooling	22046132
Intra	PPIH	O43447	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	PPIH	O43447	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PPIH	O43447	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PPIH	O43447	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PPIH	O43447	XIAP	Homo sapiens	P98170	BFG-2H	27107012
Intra	PPIH	O43447	XIAP	Homo sapiens	P98170	Y2H Array	32296183
Intra	PPIH	O43447	XIAP	Homo sapiens	P98170	Validated Y2H	27107012
Intra	PPIH	O43447	XIAP	Homo sapiens	P98170	Y2H Prey Pooling	32296183
Intra	PPIH	O43447	XIAP	Homo sapiens	P98170	Validated Y2H	32296183
Intra	PPIH	O43447	PRPF4	Homo sapiens	O43172	Y2H	22365833
Intra	PPIH	O43447	PRPF4	Homo sapiens	O43172	Y2H	16723661
Intra	PPIH	O43447	PRPF4	Homo sapiens	O43172	Pull Down	12907720
Intra	PPIH	O43447	PRPF4	Homo sapiens	O43172	X-Ray Diffraction	12875835
Intra	PPIH	O43447	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	PPIH	O43447	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	PPIH	O43447	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	PPIH	O43447	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183
Intra	PPIH	O43447	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
Intra	PPIH	O43447	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
Intra	PPIH	O43447	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PPIH	O43447	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	PPIH	O43447	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PPIH	O43447	BPIFA1	Homo sapiens	Q9NP55	Y2H Prey Pooling	32296183
Intra	PPIH	O43447	BPIFA1	Homo sapiens	Q9NP55	Validated Y2H	32296183
Intra	PPIH	O43447	BPIFA1	Homo sapiens	Q9NP55	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIH Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71029	PPIH Protein, Human (His)	O43447-1 (M1-M177)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Myxosarcoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS10953	PPIH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19937	Ppih Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26439	Ppih Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPIH	VGNC	VGNC:33200
Canis familiaris	PPIH	VGNC	VGNC:44854
Mus musculus	PPIH	MGD	MGI:106499
Felis catus	PPIH	VGNC	VGNC:80316
Rattus norvegicus	PPIH	RGD	RGD:1564921
Macaca mulatta	PPIH	VGNC	VGNC:103846
Others	PPIH	NCBI