N4BP2L2 - NEDD4 binding protein 2 like 2 Gene

Also Known as CG005; CG016; PFAAP5; 92M18.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10443

About N4BP2L2

Cytogenetic location: 13q13.1 Genomic coordinates (GRCh38): 13:32,432,485-32,538,868 (from NCBI)

This gene has 45 transcripts (splice variants), 175 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 5.4), ovary (RPKM 5.3) and 25 other tissues.

Summary

Enables enzyme binding activity. Involved in negative regulation of hematopoietic stem cell differentiation and positive regulation of hematopoietic stem cell proliferation. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]

N4BP2L2 Products (39)

mRNA Protein Name
NM_001278432.2 NP_001265361.1 NEDD4-binding protein 2-like 2 isoform 3
NM_001320836.3 NP_001307765.1 NEDD4-binding protein 2-like 2 isoform 4
NM_001387001.1 NP_001373930.1 NEDD4-binding protein 2-like 2 isoform 4
NM_001387002.1 NP_001373931.1 NEDD4-binding protein 2-like 2 isoform 4
NM_001387004.1 NP_001373933.1 NEDD4-binding protein 2-like 2 isoform 5
NM_001387005.1 NP_001373934.1 NEDD4-binding protein 2-like 2 isoform 6
NM_001387006.1 NP_001373935.1 NEDD4-binding protein 2-like 2 isoform 6
NM_001387008.1 NP_001373937.1 NEDD4-binding protein 2-like 2 isoform 7
NM_001387009.1 NP_001373938.1 NEDD4-binding protein 2-like 2 isoform 7
NM_001387015.1 NP_001373944.1 NEDD4-binding protein 2-like 2 isoform 3
NM_001387016.1 NP_001373945.1 NEDD4-binding protein 2-like 2 isoform 9
NM_001387017.1 NP_001373946.1 NEDD4-binding protein 2-like 2 isoform 5
NM_001387018.1 NP_001373947.1 NEDD4-binding protein 2-like 2 isoform 3
NM_001387019.1 NP_001373948.1 NEDD4-binding protein 2-like 2 isoform 3
NM_001387020.1 NP_001373949.1 NEDD4-binding protein 2-like 2 isoform 8
NM_001387059.1 NP_001373988.1 NEDD4-binding protein 2-like 2 isoform 19
NM_001387060.1 NP_001373989.1 NEDD4-binding protein 2-like 2 isoform 12
NM_001387079.1 NP_001374008.1 NEDD4-binding protein 2-like 2 isoform 12
NM_001387080.1 NP_001374009.1 NEDD4-binding protein 2-like 2 isoform 2
NM_001387081.1 NP_001374010.1 NEDD4-binding protein 2-like 2 isoform 15
NM_001387082.1 NP_001374011.1 NEDD4-binding protein 2-like 2 isoform 2
NM_001387083.1 NP_001374012.1 NEDD4-binding protein 2-like 2 isoform 16
NM_001387099.1 NP_001374028.1 NEDD4-binding protein 2-like 2 isoform 20
NM_001387100.1 NP_001374029.1 NEDD4-binding protein 2-like 2 isoform 17
NM_001387101.1 NP_001374030.1 NEDD4-binding protein 2-like 2 isoform 2
NM_001387102.1 NP_001374031.1 NEDD4-binding protein 2-like 2 isoform 2
NM_001387103.1 NP_001374032.1 NEDD4-binding protein 2-like 2 isoform 10
NM_001387104.1 NP_001374033.1 NEDD4-binding protein 2-like 2 isoform 11
NM_001387105.1 NP_001374034.1 NEDD4-binding protein 2-like 2 isoform 12
NM_001387106.1 NP_001374035.1 NEDD4-binding protein 2-like 2 isoform 12
NM_001387107.1 NP_001374036.1 NEDD4-binding protein 2-like 2 isoform 13
NM_001387108.1 NP_001374037.1 NEDD4-binding protein 2-like 2 isoform 13
NM_001387165.1 NP_001374094.1 NEDD4-binding protein 2-like 2 isoform 18
NM_001387223.1 NP_001374152.1 NEDD4-binding protein 2-like 2 isoform 16
NM_001387224.1 NP_001374153.1 NEDD4-binding protein 2-like 2 isoform 15
NM_001387225.1 NP_001374154.1 NEDD4-binding protein 2-like 2 isoform 14
NM_001395224.1 NP_001382153.1 NEDD4-binding protein 2-like 2 isoform 21
NM_014887.3 NP_055702.1 NEDD4-binding protein 2-like 2 isoform 2
NM_033111.5 NP_149102.3 NEDD4-binding protein 2-like 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
19506020 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19506020 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
19506020 GOA
involved in positive regulation of hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
19506020 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19506020 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
19506020 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

N4BP2L2 Protein Structure

AAA_33

AAA_33: AAA domain (404 - 536)

  • 0
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  • 200
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  • 400
  • 500
  • 583 a.a.
Protein Preferred Names Protein Names

NEDD4-binding protein 2-like 2

  • phosphonoformate immuno-associated protein 5

N4BP2L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
N4BP2L2 Q92802 PPIH Homo sapiens O43447
Y2H Array
25416956
Intra
N4BP2L2 Q92802 PPIL1 Homo sapiens Q9Y3C6
Validated Y2H
32296183
Intra
N4BP2L2 Q92802 HOXA1 Homo sapiens P49639
Validated Y2H
25416956
Intra
N4BP2L2 Q92802 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
25416956
Intra
N4BP2L2 Q92802 NAA38 Homo sapiens Q9BRA0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08982 N4BP2L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus N4BP2L2 MGD MGI:2687207
Macaca mulatta N4BP2L2 VGNC VGNC:75031
Canis familiaris N4BP2L2 VGNC VGNC:59086
Rattus norvegicus N4BP2L2 RGD RGD:1359603
Bos taurus N4BP2L2 VGNC VGNC:53827
Others N4BP2L2 NCBI