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Adam17 - a disintegrin and metallopeptidase domain 17 Gene

Also Known as Tace; CD156b

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11491

About Adam17

Chromosome 12: 21,373,510-21,423,633 reverse strand.GRCm39:CM001005.3

This gene has 10 transcripts (splice variants), 283 orthologues, 35 paralogues and is associated with 123 phenotypes. Ubiquitous expression in placenta adult (RPKM 12.8), CNS E11.5 (RPKM 9.9) and 28 other tissues.

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]

Adam17 Products (3)

mRNA	Protein	Name
NM_001277266.1	NP_001264195.1	disintegrin and metalloproteinase domain-containing protein 17 isoform 2 precursor
NM_009615.6	NP_033745.4	disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein
NM_001291871.1	NP_001278800.1	disintegrin and metalloproteinase domain-containing protein 17 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	17245433	MGI
enables metallodipeptidase activity	IMP IMP: Inferred from mutant phenotype	14993236	MGI
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	14993236	MGI
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	14761956	MGI
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	14993236	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15574878	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	17371977	MGI
involved in T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	17371977	MGI
involved in cell motility	IMP IMP: Inferred from mutant phenotype	18625725	MGI
involved in germinal center formation	IMP IMP: Inferred from mutant phenotype	17371977	MGI
acts upstream of or within membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	26651291	MGI
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	15691827	MGI
acts upstream of or within membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	26651291	MGI
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	9034190	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	18687778	MGI
acts upstream of or within negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	26651291	MGI
acts upstream of positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18625725	MGI
involved in production of molecular mediator involved in inflammatory response	IDA IDA: Inferred from direct assay	20610799	MGI
acts upstream of or within regulation of axon regeneration	IGI IGI: Inferred from genetic interaction	26651291	MGI
involved in regulation of mast cell apoptotic process	IMP IMP: Inferred from mutant phenotype	14625290	MGI
acts upstream of or within regulation of neuron migration	IGI IGI: Inferred from genetic interaction	26651291	MGI
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	16179345	MGI
involved in signaling receptor ligand precursor processing	IMP IMP: Inferred from mutant phenotype	14993236	MGI
involved in spleen development	IMP IMP: Inferred from mutant phenotype	17371977	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15739225	MGI
located in membrane	IDA IDA: Inferred from direct assay	26651291	MGI
is active in plasma membrane	IMP IMP: Inferred from mutant phenotype	14993236	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adam17 Protein Structure

Pep_M12B_propep

ZnMc_TACE_like

DISIN

ADAM17_MPD

0
200
400
600
827 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 17	TNF-alpha convertase TNF-alpha converting enzyme

Recombinant Adam17 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P78717	ADAM17/TACE Protein, Mouse (HEK293, His)	Q9Z0F8 (P18-D563)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-10293	Aderbasib	Inhibitor	99.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-115670	GW280264X	Inhibitor	99.30%	Unkown
HY-16657	TAPI-1	Inhibitor	99.36%	Unkown
HY-110397	KP-457	Inhibitor	98.88%	Unkown
HY-120852	JG26	Inhibitor	98.14%	Unkown
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.54%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2	Substrate	99.33%	Unkown
HY-175876	ADAM17-IN-1	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P992406	MEDI-3622	Inhibitor	/	Unkown
HY-P992341	D8P1C1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam17	NCBI	NCBI:6868