Hpgd - hydroxyprostaglandin dehydrogenase 15 (NAD) Gene

Also Known as 15-PGDH

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15446

About Hpgd

Chromosome 8: 56,747,620-56,774,078 forward strand.GRCm39:CM001001.3

This gene has 1 transcript (splice variant), 204 orthologues and is associated with 9 phenotypes. Broad expression in lung adult (RPKM 76.), bladder adult (RPKM 5.8) and 17 other tissues.

Summary

Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. Involved in ductus arteriosus closure. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; choroid plexus; humerus cartilage condensation; nose; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Hpgd Products (1)

mRNA Protein Name
NM_008278.2 NP_032304.2 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
15542609 MGI
Biological Process GO Annotation Evidence Références Source
involved in ductus arteriosus closure IMP
IMP: Inferred from mutant phenotype
11821873 MGI
Cellular Component GO Annotation Evidence Références Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
20448048 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hpgd Protein Structure

ADH_SDR_c_like

ADH_SDR_c_like: cd05323 (5 - 253)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

  • 15-hydroxyprostaglandin dehydrogenase

  • PGDH

  • eicosanoid/docosanoid dehydrogenase

  • prostaglandin dehydrogenase 1

Recombinant Hpgd Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75555 15-PGDH/HPGD Protein, Mouse (His) Q8VCC1 (M1-S269) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-116449 2-Benzoylthiophene 99.90% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-108259 HQL-79 Inhibitor 99.89% Unkown
HY-10439 HPGDS inhibitor 1 Inhibitor 99.42% Unkown
HY-12791 hPGDS-IN-1 Inhibitor 99.92% Unkown
HY-139972 PROTAC(H-PGDS)-7 99.42% Unkown
HY-110167 TFC 007 Inhibitor 98.01% Unkown
HY-126134 HPGDS inhibitor 2 Inhibitor 99.70% Unkown
HY-146662 HPGDS inhibitor 3 Inhibitor / Unkown
HY-157577 PROTAC(H-PGDS)-8 Degrader / Unkown
HY-RS06338 HPGD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06339 Hpgd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06340 Hpgd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06341 HPGDS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120581 ML388 Inhibitor / Unkown
HY-139171 F092 Inhibitor 99.79% Unkown
HY-RS17229 Hpgds Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23682 Hpgds Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hpgd NCBI NCBI:3248