15-PGDH/HPGD Protein, Mouse (His)

The 15-PGDH/HPGD protein catalyzes the NAD-dependent dehydrogenation of various hydroxylated polyunsaturated fatty acids (mainly eicosanoids and behenic acid). 15-PGDH/HPGD Protein, Mouse (His) is the recombinant mouse-derived 15-PGDH/HPGD protein, expressed by E. coli , with C-His labeled tag. The total length of 15-PGDH/HPGD Protein, Mouse (His) is 269 a.a., with molecular weight of ~30 kDa.

15-PGDH/HPGD protein plays a pivotal role in catalyzing the NAD-dependent dehydrogenation (oxidation) of a diverse range of hydroxylated polyunsaturated fatty acids, predominantly eicosanoids and docosanoids, including prostaglandins, lipoxins, and resolvins, resulting in the formation of their corresponding keto (oxo) metabolites. This enzymatic activity is crucial for modulating cellular responses, particularly by reducing the levels of pro-proliferative prostaglandins such as prostaglandin E2. By generating oxo-fatty acid products, 15-PGDH/HPGD can profoundly influence cell function and counteract the inflammatory effects of certain cytokines. Furthermore, the enzyme plays a role in inactivating resolvins, including resolvins E1, D1, and D2, which are involved in the resolution phase of acute inflammation and obesity-induced adipose inflammation.

Mouse

E. coli

C-His

Q8VCC1 (M1-S269)

15446  [NCBI]

Approximately 30 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.